Pharmacology and Toxicology Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Pharmacy Practice Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Medicine (Baltimore). 2024 May 24;103(21):e38245. doi: 10.1097/MD.0000000000038245.
Glioblastoma (GBM) is a highly aggressive primary malignant brain tumor with a dismal prognosis despite current treatment strategies. Inflammation plays an essential role in GBM pathophysiology, contributing to tumor growth, invasion, immunosuppression, and angiogenesis. As a result, pharmacological intervention with anti-inflammatory drugs has been used as a potential approach for the management of GBM. To provide an overview of the current understanding of GBM pathophysiology, potential therapeutic applications of anti-inflammatory drugs in GBM, conventional treatments of glioblastoma and emerging therapeutic approaches currently under investigation. A narrative review was carried out, scanning publications from 2000 to 2023 on PubMed and Google Scholar. The search was not guided by a set research question or a specific search method but rather focused on the area of interest. Conventional treatments such as surgery, radiotherapy, and chemotherapy have shown some benefits, but their effectiveness is limited by various factors such as tumor heterogeneity and resistance.
胶质母细胞瘤（GBM）是一种高度侵袭性的原发性恶性脑肿瘤，尽管目前有治疗策略，但预后仍然不佳。炎症在 GBM 的病理生理学中起着至关重要的作用，导致肿瘤生长、侵袭、免疫抑制和血管生成。因此，使用抗炎药物进行药物干预已被用作 GBM 管理的一种潜在方法。本文旨在概述 GBM 的病理生理学、抗炎药物在 GBM 中的潜在治疗应用、胶质母细胞瘤的常规治疗以及目前正在研究的新兴治疗方法。我们进行了叙述性综述，在 PubMed 和 Google Scholar 上搜索了 2000 年至 2023 年的出版物。搜索没有遵循一套既定的研究问题或特定的搜索方法，而是侧重于感兴趣的领域。手术、放疗和化疗等常规治疗方法已经显示出一些益处，但它们的有效性受到肿瘤异质性和耐药性等多种因素的限制。
