Alaeddini M, Salah S, Dehghan F, Eshghyar N, Etemad-Moghadam S
Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Oral Dis. 2009 Sep;15(6):422-7. doi: 10.1111/j.1601-0825.2009.01566.x. Epub 2009 Apr 21.
The aim of the present study was to evaluate and compare angiogenesis in keratocystic odontogenic tumours, dentigerous cysts (DCs) and ameloblasomas using monoclonal antibody against CD34.
Microvessel density was assessed in a total of 53 cases including 20 keratocystic odontogenic tumours, 13 DCs and 20 ameloblastomas (14 solid and six unicystic variants). Microvessel density was expressed as the mean number of microvessels per high-power-field.
Statistically significant differences in mean microvessel density were observed between keratocystic odontogenic tumours, DCs and solid ameloblastomas (P < 0.001). Mean microvessel density was significantly higher in solid ameloblastomas compared with both keratocystic odontogenic tumours and DCs; and was also significantly higher in keratocystic odontogenic tumours than in DCs.
Within the limitations of the present study, it can be suggested that angiogenesis may be one of the mechanisms possibly contributing to the different biological behaviours of keratocystic odontogenic tumours, DCs and solid ameloblastomas.
本研究旨在使用抗CD34单克隆抗体评估和比较牙源性角化囊性瘤、含牙囊肿（DCs）和成釉细胞瘤中的血管生成情况。
共评估了53例病例的微血管密度，其中包括20例牙源性角化囊性瘤、13例含牙囊肿和20例成釉细胞瘤（14例实性和6例单囊性变体）。微血管密度表示为每高倍视野微血管的平均数。
牙源性角化囊性瘤、含牙囊肿和实性成釉细胞瘤之间的平均微血管密度存在统计学显著差异（P < 0.001）。实性成釉细胞瘤的平均微血管密度显著高于牙源性角化囊性瘤和含牙囊肿；牙源性角化囊性瘤的平均微血管密度也显著高于含牙囊肿。
在本研究的局限性内，可以认为血管生成可能是导致牙源性角化囊性瘤、含牙囊肿和实性成釉细胞瘤不同生物学行为的机制之一。
