Sulaiman H A
Department of Internal Medicine, University of Indonesia Faculty of Medicine, Jakarta.
Gastroenterol Jpn. 1989 Oct;24(5):567-72. doi: 10.1007/BF02773887.
A prospective study was carried out in 126 cases with liver cirrhosis attending the outpatient clinic of Hepatology of the Department of Internal Medicine, Dr. Cipto Mangunkusmo Hospital Jakarta, between August 1, 1982 and Dec. 31, 1985. The patients consisted of 82 men and 44 women and there were 45 HBsAg positive cases (36.7%). HBeAg was positive in 35.6% (16/45) and 40.0% were anti-HBe positive while both markers were negative in 24.4%. During the follow-up study 27 cases died. The cause of death was due to variceal bleeding in 9 cases (33.3%) and hepatic failure in 9 cases (33.3%). In 6 cases (22.2%) hepatocellular carcinoma (HCC) was the cause of death. Nine cases out of 94 traceable cases (13.7%) were developed HCC. They consisted of 4 cases out of 29 cases (13.8%) with HBsAg positive and 5 cases out of 65 cases (7.7%). But no significant difference was observed between both groups. The length of observation period from the first time of diagnosis until development of HCC was from 1 to 6 years with an average of 2.9 years.
1982年8月1日至1985年12月31日期间，在雅加达Cipto Mangunkusmo医院内科肝病门诊对126例肝硬化患者进行了一项前瞻性研究。患者包括82名男性和44名女性，其中45例HBsAg阳性（36.7%）。HBeAg阳性率为35.6%（16/45），抗-HBe阳性率为40.0%，两种标志物均阴性的占24.4%。在随访研究中，27例患者死亡。死亡原因是静脉曲张出血9例（33.3%），肝衰竭9例（33.3%）。6例（22.2%）死于肝细胞癌（HCC）。94例可追踪病例中有9例（13.7%）发生了HCC。其中HBsAg阳性的29例中有4例（13.8%），65例中5例（7.7%）。但两组之间未观察到显著差异。从首次诊断到发生HCC的观察期为1至6年，平均为2.9年。
