Lingao A L
Department of Medicine, College of Medicine, University of Phillipines, Manila.
Gastroenterol Jpn. 1989 Aug;24(4):425-33. doi: 10.1007/BF02774352.
The relationship between hepatitis B virus (HBV) infection and cirrhosis (CIR) and hepatocellular carcinoma (HCC) was investigated. 340 cases with HCC and 99 cases with CIR were compared with the control group which were asymoptomatic age- and sex-matched case. Both HCC and CIR have higher infection rated of HBV and the positivity rated of HBsAg than their controls in both sexes. The positivity rate (74.8%) of HBsAg in HCC is significantly higher than that (58.2%) in CIR. HBeAg is more frequently positive in CIR than in HCC, especially among females. There was no sex difference in HBsAg positive among HCC nor among CIR. Age-adjusted AFP elevation is significantly more frequent in HBsAg-positive HCC than in HBsAg-negative. Both HCC and CIR in the Philippines are closely associated with HBV infection. The association with the infection is stronger with HCC than with CIR. Other causative/contributary factors may be important, especially with CIR. However, the great majority of HCC are probably due to chronic HBV infection, the public health control of which may result in a significant diminution of the malignancy in the country.
对乙型肝炎病毒（HBV）感染与肝硬化（CIR）及肝细胞癌（HCC）之间的关系进行了研究。将340例肝细胞癌患者和99例肝硬化患者与年龄和性别相匹配的无症状对照组进行比较。肝细胞癌和肝硬化患者的HBV感染率及HBsAg阳性率均高于各自的对照组，且男女皆是如此。肝细胞癌患者的HBsAg阳性率（74.8%）显著高于肝硬化患者（58.2%）。HBeAg在肝硬化患者中比在肝细胞癌患者中更常呈阳性，尤其是在女性中。肝细胞癌患者和肝硬化患者中HBsAg阳性率均无性别差异。在年龄调整后，HBsAg阳性的肝细胞癌患者甲胎蛋白升高的频率显著高于HBsAg阴性者。菲律宾的肝细胞癌和肝硬化均与HBV感染密切相关。与感染的关联在肝细胞癌中比在肝硬化中更强。其他致病/促成因素可能很重要，尤其是对肝硬化而言。然而，绝大多数肝细胞癌可能归因于慢性HBV感染，对其进行公共卫生控制可能会使该国的恶性肿瘤显著减少。
