Narendran A, Hoffman S A
Department of Microbiology, Arizona State University, Tempe 85287.
J Neuroimmunol. 1989 Sep;24(1-2):113-23. doi: 10.1016/0165-5728(89)90105-7.
Using the Western blot technique we analyzed the sera of five strains of mice that develop a disease like systemic lupus erythematosus (SLE), along with two normal strains, for their binding specificities against isolated mouse integral brain membrane proteins. This report describes the distribution and frequency of the more than 200 brain-reactive autoantibodies in the 126 animals tested and verifies the hypothesis of diversity in anti-brain antibodies produced during autoimmune conditions such as SLE. These results emphasize the importance of characterizing the brain-reactive autoantibodies in the sera or cerebrospinal fluid of SLE patients with central nervous system involvement.
我们运用蛋白质免疫印迹技术，分析了五株会患上类似系统性红斑狼疮（SLE）疾病的小鼠血清，以及两株正常小鼠的血清，以检测它们与分离出的小鼠完整脑膜蛋白的结合特异性。本报告描述了在126只受试动物中200多种脑反应性自身抗体的分布和频率，并验证了在诸如SLE等自身免疫性疾病过程中产生的抗脑抗体具有多样性这一假说。这些结果强调了对患有中枢神经系统受累的SLE患者血清或脑脊液中的脑反应性自身抗体进行特征分析的重要性。
