Walsh L J, Tseng P W, Savage N W, Seymour G J
Department of Social and Preventive Dentistry, University of Queensland, Brisbane, Australia.
J Oral Pathol Med. 1989 Jul;18(6):360-5. doi: 10.1111/j.1600-0714.1989.tb01566.x.
The CD45R and CDw29 antigens are expressed on naive and primed helper T cell populations which serve suppressor-inducer or helper-inducer functions, respectively. These antigens may also be expressed on epithelial cell subpopulations. In the present study, monoclonal antibodies reacting with T lymphocytes and Langerhans cells (LC) were used to characterize the expression of CD45R and CDw29 antigens in oral lichen planus. CDw29 was expressed by LC and lymphocytic cells whereas keratinocyte reactivity varied from negative through to full thickness staining. Expression of CD45R was confined to intraepithelial cells with either lymphocytic or dendritic morphology. A relatively constant ratio of CD1a + LC to CD45R + cells (2:1) was seen. These results demonstrate the existence of intraepithelial cells expressing antigens which are functionally important in T cell responses and which may provide local immunoregulatory influences.
CD45R和CDw29抗原分别在幼稚和致敏辅助性T细胞群体上表达，这些细胞群体分别发挥抑制诱导或辅助诱导功能。这些抗原也可能在上皮细胞亚群上表达。在本研究中，使用与T淋巴细胞和朗格汉斯细胞（LC）反应的单克隆抗体来表征口腔扁平苔藓中CD45R和CDw29抗原的表达。CDw29由LC和淋巴细胞表达，而角质形成细胞的反应性从阴性到全层染色不等。CD45R的表达局限于具有淋巴细胞或树突状形态的上皮内细胞。观察到CD1a + LC与CD45R +细胞的比例相对恒定（2:1）。这些结果表明存在表达抗原的上皮内细胞，这些抗原在T细胞反应中具有重要功能，并且可能提供局部免疫调节影响。
