组胺直接控制龙虾嗅觉受体神经元中的氯离子通道。
Histamine directly gates a chloride channel in lobster olfactory receptor neurons.
作者信息
McClintock T S, Ache B W
机构信息
Whitney Laboratory, University of Florida, Saint Augustine 32086.
出版信息
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8137-41. doi: 10.1073/pnas.86.20.8137.
Abstract
Biogenic amines mediate many types of intercellular communication in multicellular organisms. Heretofore, little direct evidence has indicated that biogenic amines produce intracellular responses other than by triggering the enzymatic production of second messengers. Our electrophysiological studies of lobster olfactory receptor neurons now reveal that one biogenic amine, histamine, can directly gate an ion channel. The channel responds to histamine concentrations of 1 microM or more, is permeable primarily to Cl-, is more active at depolarized potentials, and has a conductance of 44 pS in the American lobster and 66 pS in the Caribbean spiny lobster. The expression of this ligand-gated channel in olfactory receptor neurons implies that these neurons are targets of a regulatory or feedback process.
摘要
生物胺在多细胞生物中介导多种类型的细胞间通讯。迄今为止，几乎没有直接证据表明生物胺除了通过触发第二信使的酶促产生之外还能产生细胞内反应。我们对龙虾嗅觉受体神经元的电生理研究现在表明，一种生物胺——组胺，可以直接控制离子通道。该通道对1微摩尔或更高浓度的组胺有反应，主要对Cl-通透，在去极化电位下更活跃，在美国龙虾中的电导为44皮安，在加勒比刺龙虾中的电导为66皮安。这种配体门控通道在嗅觉受体神经元中的表达意味着这些神经元是调节或反馈过程的靶点。
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