Hatt H, Ache B W
Physiologisches Institut, TU München, Germany.
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6264-8. doi: 10.1073/pnas.91.14.6264.
The idea of having two second messenger pathways in olfaction, one mediated by cAMP and the other by inositol 1,4,5-trisphosphate, is supported by evidence that both second messengers directly activate distinct ion channels in the outer dendrite of lobster olfactory receptor neurons. Evidence that both types of second messenger-gated channels can occur in the same patch of membrane suggests that channels of both types can be expressed in one neuron. Evidence of more than one type of inositol phosphate-gated channel in this highly specialized region of the neuron furthers the idea that the output of individual olfactory receptor cells is regulated through multiple effectors and allows that effector diversity may contribute to functional diversity among olfactory receptor cells.
嗅觉中存在两条第二信使通路的观点得到了证据支持，一条由环磷酸腺苷（cAMP）介导，另一条由肌醇1,4,5 -三磷酸介导。证据表明，这两种第二信使都能直接激活龙虾嗅觉受体神经元外树突中不同的离子通道。两种类型的第二信使门控通道可出现在同一细胞膜片上的证据表明，这两种类型的通道都可在一个神经元中表达。在神经元的这个高度特化区域中存在不止一种类型的肌醇磷酸门控通道，这进一步支持了个体嗅觉受体细胞的输出是通过多种效应器进行调节的观点，并表明效应器的多样性可能有助于嗅觉受体细胞之间的功能多样性。
