Kannan Arun, Janardhanan Rajesh
Section of Cardiology, Sarver Heart Center, University of Arizona College of Medicine, Tucson, AZ, USA,
Curr Hypertens Rep. 2014 Jul;16(7):447. doi: 10.1007/s11906-014-0447-7.
Hypertension remains a significant risk factor for development of congestive heart failure CHF), with various mechanisms contributing to both systolic and diastolic dysfunction. The pathogenesis of myocardial changes includes structural remodeling, left ventricular hypertrophy, and fibrosis. Activation of the sympathetic nervous system and renin-angiotensin system is a key contributing factor of hypertension, and thus interventions that antagonize these systems promote regression of hypertrophy and heart failure. Control of blood pressure is of paramount importance in improving the prognosis of patients with heart failure.
高血压仍然是发生充血性心力衰竭（CHF）的一个重要危险因素，多种机制导致收缩和舒张功能障碍。心肌变化的发病机制包括结构重塑、左心室肥厚和纤维化。交感神经系统和肾素-血管紧张素系统的激活是高血压的一个关键促成因素，因此拮抗这些系统的干预措施可促进肥厚和心力衰竭的消退。控制血压对于改善心力衰竭患者的预后至关重要。
