Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States.
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Curr Opin Genet Dev. 2014 Apr;25:131-7. doi: 10.1016/j.gde.2013.11.009. Epub 2014 May 8.
The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations.
染色体结构维持（SMC）复合物与转录增强子、启动子和绝缘子有关，它们有助于控制基因表达和基因组结构。在这里，我们回顾了 SMC 复合物在基因表达和基因组结构中的相互关联作用的最新研究进展。其中，我们注意到证据表明 SMC 复合物在控制细胞身份的基因调控中发挥重要作用。最后，我们回顾了与 SMC 突变相关的疾病。
