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1
A single amino acid mutation in a protein antigen abrogates presentation of certain T cell determinants.蛋白质抗原中的单个氨基酸突变会消除某些T细胞决定簇的呈递。
J Exp Med. 1989 Dec 1;170(6):2171-6. doi: 10.1084/jem.170.6.2171.
2
The T cell repertoire for recognition of a phylogenetically distant protein antigen. Peptide specificity and MHC restriction of staphylococcal nuclease-specific T cell clones.用于识别系统发育上远缘蛋白质抗原的T细胞库。葡萄球菌核酸酶特异性T细胞克隆的肽特异性和MHC限制。
J Exp Med. 1986 Sep 1;164(3):897-910. doi: 10.1084/jem.164.3.897.
3
Identification of single amino acid substitutions in the staphylococcal nuclease protein that enhance and diminish T cell clone recognition of naturally processed peptides.鉴定葡萄球菌核酸酶蛋白中的单个氨基酸取代，这些取代增强和减弱T细胞克隆对天然加工肽的识别。
Int Immunol. 1992 Dec;4(12):1399-406. doi: 10.1093/intimm/4.12.1399.
4
Sequences outside a minimal immunodominant site exert negative effects on recognition by staphylococcal nuclease-specific T cell clones.最小免疫显性位点之外的序列对葡萄球菌核酸酶特异性T细胞克隆的识别产生负面影响。
J Immunol. 1989 Nov 1;143(9):2814-9.
5
Interference with the binding of a naturally processed peptide to class II alters the immunodominance of T cell epitopes in vivo.干扰天然加工的肽与II类分子的结合会改变体内T细胞表位的免疫显性。
J Immunol. 1994 Aug 1;153(3):1015-26.
6
Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nuclease.单个氨基酸取代改变了金黄色葡萄球菌核酸酶抗原加工过程中的T细胞决定簇选择。
J Immunol. 1991 Jan 15;146(2):438-43.
7
T cell activation by processed antigen is equally blocked by I-E and I-A-restricted immunodominant peptides.经处理的抗原对T细胞的激活同样会被I-E和I-A限制性免疫显性肽所阻断。
Eur J Immunol. 1987 Nov;17(11):1605-9. doi: 10.1002/eji.1830171113.
8
The immunodominant region of Staphylococcal nuclease is represented by multiple peptide sequences.葡萄球菌核酸酶的免疫显性区域由多个肽序列代表。
Cell Immunol. 1996 Sep 15;172(2):254-61. doi: 10.1006/cimm.1996.0240.
9
Immunodominance: a single amino acid substitution within an antigenic site alters intramolecular selection of T cell determinants.免疫显性：抗原位点内的单个氨基酸取代改变了T细胞决定簇的分子内选择。
J Immunol. 1993 Aug 15;151(4):1852-8.
10
Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations.利用鸽细胞色素c特异性T细胞杂交瘤分析不同主要组织相容性复合体/T细胞受体复合物中的肽结合模式。单一肽以不同构象结合主要组织相容性复合体的证据。
J Exp Med. 1989 Nov 1;170(5):1609-25. doi: 10.1084/jem.170.5.1609.

本文引用的文献

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Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.氨和氯喹引起的巨噬细胞抗原分解代谢减少与抗原呈递给T细胞的抑制相关。
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Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain.小鼠I-Eβ多肽链cDNA克隆的分离与鉴定
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7621-5. doi: 10.1073/pnas.80.24.7621.
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Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.H-2 限制性 T 细胞的抗原识别。I. 无细胞抗原处理。
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The nucleotide sequence of the murine I-E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex.小鼠I-Eβb免疫反应基因的核苷酸序列：主要组织相容性复合体II类基因中基因转换事件的证据。
EMBO J. 1984 Jun;3(6):1221-5. doi: 10.1002/j.1460-2075.1984.tb01956.x.
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Binding of immunogenic peptides to Ia histocompatibility molecules.免疫原性肽与Ia组织相容性分子的结合。
Nature. 1985;317(6035):359-61. doi: 10.1038/317359a0.
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7
Class I cross-restricted T cells reveal low responder allele due to processing of viral antigen.I类交叉限制性T细胞因病毒抗原的加工而显示低反应性等位基因。
Nature. 1989 Feb 16;337(6208):653-5. doi: 10.1038/337653a0.
8
A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes.一种作为MHC I类限制性T淋巴细胞最小抗原决定簇的五肽。
Nature. 1989 Feb 16;337(6208):651-3. doi: 10.1038/337651a0.
9
Mechanisms influencing the immunodominance of T cell determinants.影响T细胞决定簇免疫显性的机制。
J Exp Med. 1988 Dec 1;168(6):2091-104. doi: 10.1084/jem.168.6.2091.
10
Influences of antigen processing on the expression of the T cell repertoire. Evidence for MHC-specific hindering structures on the products of processing.抗原加工对T细胞受体库表达的影响。加工产物上存在MHC特异性阻碍结构的证据。
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蛋白质抗原中的单个氨基酸突变会消除某些T细胞决定簇的呈递。

A single amino acid mutation in a protein antigen abrogates presentation of certain T cell determinants.

作者信息

Finnegan A, Amburgey C F

机构信息

Department of Internal Medicine, Rush-Presbyterian-St. Luke's Medical School, Chicago, Illinois 60612.

出版信息

J Exp Med. 1989 Dec 1;170(6):2171-6. doi: 10.1084/jem.170.6.2171.

DOI:10.1084/jem.170.6.2171
PMID:2479708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189545/
Abstract

Nase-specific T cell recognize the 86-100 peptide in association with B10.A APC. Clone N40 recognizes the 86-100 peptide in association with B10.A (Ek alpha Ek beta) and B10.A (5R) (Ek alpha Eb beta) APCs. We demonstrate here that a single amino acid substitution in the staphylococcal nuclease protein alters the structure of the processed peptide such that the T cell epitope recognized by clone N40 was only available for recognition in conjunction with B10.A (5R) but not the B10.A APCs. Other Nase-specific T cells recognize the mutant nuclease, and a synthetic peptide corresponding to the immunodominant region of the mutant protein was stimulatory for all the Nase-specific T cells. These results suggest that the mutation either affects the processing of the protein into antigenic peptides or affects the conformation of the processed fragment differently from that of the peptide.

摘要

鼻腔特异性T细胞识别与B10.A抗原呈递细胞相关的86 - 100肽段。克隆N40识别与B10.A（EkαEkβ）和B10.A（5R）（EkαEbβ）抗原呈递细胞相关的86 - 100肽段。我们在此证明，葡萄球菌核酸酶蛋白中的单个氨基酸取代会改变加工后肽段的结构，使得克隆N40识别的T细胞表位仅能与B10.A（5R）结合被识别，而不能与B10.A抗原呈递细胞结合被识别。其他鼻腔特异性T细胞识别突变型核酸酶，并且对应于突变蛋白免疫显性区域的合成肽对所有鼻腔特异性T细胞都有刺激作用。这些结果表明，该突变要么影响蛋白质加工成抗原肽的过程，要么以不同于肽段的方式影响加工片段的构象。