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克隆的原猴亚目灵长类短散在核元件（SINE）序列的体内转录

In vivo transcription of a cloned prosimian primate SINE sequence.

作者信息

Slagel V K, Deininger P L

机构信息

Department of Biological Chemistry, UCLA School of Medicine 90024.

出版信息

Nucleic Acids Res. 1989 Nov 11;17(21):8669-82. doi: 10.1093/nar/17.21.8669.

DOI:10.1093/nar/17.21.8669
PMID:2479909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC335035/
Abstract

SINE transcription was studied by introducing a galago Monomer family member (gal39), into the mouse Ltk- cell line. Cells transiently transfected with gal39 produce gal39-specific RNA polymerase III-directed transcripts. In permanent cell lines gal39 expression was largely shut off. Genomic environment, copy number and tandem repetition of integrated SINE sequences influenced whether or not RNA polymerase III-directed gal39 transcripts were detectable. These transcripts differ in length from the observed endogenous transcript in cultured galago cells which hybridizes to this repetitive DNA family.

摘要

通过将一个夜猴单体家族成员（gal39）导入小鼠Ltk-细胞系来研究SINE转录。用gal39瞬时转染的细胞产生gal39特异性的RNA聚合酶III指导的转录本。在永久细胞系中，gal39的表达在很大程度上被关闭。整合的SINE序列的基因组环境、拷贝数和串联重复影响了是否能检测到RNA聚合酶III指导的gal39转录本。这些转录本的长度与在培养的夜猴细胞中观察到的与这个重复DNA家族杂交的内源性转录本不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/2c32700452af/nar00138-0275-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/13d68b22c32d/nar00138-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/19c7e398e83a/nar00138-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/385b3f586785/nar00138-0272-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/411b3bac34f1/nar00138-0274-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/2c32700452af/nar00138-0275-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/13d68b22c32d/nar00138-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/19c7e398e83a/nar00138-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/385b3f586785/nar00138-0272-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/411b3bac34f1/nar00138-0274-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b11b/335035/2c32700452af/nar00138-0275-a.jpg

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本文引用的文献

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