灵长类基因组中Alu家族重复DNA序列的第二大类。
A second major class of Alu family repeated DNA sequences in a primate genome.
作者信息
Daniels G R, Deininger P L
出版信息
Nucleic Acids Res. 1983 Nov 11;11(21):7595-610. doi: 10.1093/nar/11.21.7595.
We have analyzed repetitive DNA sequences in a prosimian, Galago crassicaudatus, and found that there are two distinct, highly repetitive families of sequences related to the human Alu family. The Type I family is closely analogous to the human Alu Family. The Type II family of repeats, which appears to be present in higher copy number, has a right half that is almost identical to the Type I family. However, the left half of the Type II sequence shows only limited homology to the galago Type I or human Alu families. A comparison of homologous sequences in the left half indicated that they are centered in regions of the Alu family which function as RNA polymerase III promoters. We have also observed at least one example of a Type II left half that was integrated into the genome independent of the Alu family right half sequence. The Type II family appears to be of much more recent evolutionary origin than the Type I and may have arisen by the independent integration of a RNA polymerase III promoter adjacent to the right half of a Type I Alu family sequence.
我们分析了一种原猴类动物——粗尾婴猴（Galago crassicaudatus）中的重复DNA序列，发现存在两个与人类Alu家族相关的不同的高度重复序列家族。I型家族与人类Alu家族极为相似。II型重复序列家族的拷贝数似乎更高，其右半部分几乎与I型家族相同。然而，II型序列的左半部分与婴猴I型家族或人类Alu家族仅显示出有限的同源性。对左半部分同源序列的比较表明，它们集中在Alu家族中作为RNA聚合酶III启动子的区域。我们还观察到至少一个II型左半部分独立于Alu家族右半部分序列整合到基因组中的例子。II型家族的进化起源似乎比I型家族要近得多，可能是由一个RNA聚合酶III启动子独立整合到I型Alu家族序列的右半部分旁边而产生的。
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