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为什么我们需要肠道微生物群来应对癌症治疗？

Why should we need the gut microbiota to respond to cancer therapies?

作者信息

Viaud Sophie, Daillère Romain, Yamazaki Takahiro, Lepage Patricia, Boneca Ivo, Goldszmid Romina, Trinchieri Giorgio, Zitvogel Laurence

机构信息

Institut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.

Institut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France.

出版信息

Oncoimmunology. 2014 Jan 1;3(1):e27574. doi: 10.4161/onci.27574. Epub 2014 Jan 17.

DOI:10.4161/onci.27574
PMID:24800167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4006853/
Abstract

Cyclophosphamide, one of the most efficient tumoricidal, antiangiogenic, and immunostimulatory drugs employed to date mediates part of its effects through intestinal bacteria, against which the host becomes immunized during treatment. Our recent work suggests that anti-commensal effector pT17 and memory T1 CD4 T-cell responses are indispensable for optimal anticancer effects as mediated by cyclophosphamide.

摘要

环磷酰胺是迄今为止使用的最有效的杀肿瘤、抗血管生成和免疫刺激药物之一，其部分作用是通过肠道细菌介导的，宿主在治疗过程中会针对这些细菌产生免疫。我们最近的研究表明，抗共生效应性pT17和记忆性T1 CD4 T细胞反应对于环磷酰胺介导的最佳抗癌效果不可或缺。

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本文引用的文献

1
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.肠道微生物群调节环磷酰胺的抗癌免疫作用。
Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537.
2
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.共生菌通过调节肿瘤微环境来控制癌症对治疗的反应。
Science. 2013 Nov 22;342(6161):967-70. doi: 10.1126/science.1240527.
3
Improving the outcome of adoptive cell transfer by targeting tumor escape.通过靶向肿瘤逃逸改善过继性细胞转移的疗效。
粪便微生物群移植的抗肿瘤作用：对癌症治疗中微生物组调节的启示。
Front Immunol. 2022 Sep 13;13:949490. doi: 10.3389/fimmu.2022.949490. eCollection 2022.
4
Impact of Levofloxacin for the Prophylaxis of Bloodstream Infection on the Gut Microbiome in Patients With Hematologic Malignancy.左氧氟沙星预防血流感染对血液系统恶性肿瘤患者肠道微生物群的影响
Open Forum Infect Dis. 2019 May 31;6(7):ofz252. doi: 10.1093/ofid/ofz252. eCollection 2019 Jul.
5
Tuning cancer fate: the unremitting role of host immunity.调控癌症转归：宿主免疫的不懈作用
Open Biol. 2017 Apr;7(4). doi: 10.1098/rsob.170006.
6
Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.早期使用广谱抗生素引起的微生物群破坏是异基因造血干细胞移植后预后的独立危险因素。
Biol Blood Marrow Transplant. 2017 May;23(5):845-852. doi: 10.1016/j.bbmt.2017.02.006. Epub 2017 Feb 14.
7
Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy.试验观察：用于抗癌化疗的免疫原性细胞死亡诱导剂
Oncoimmunology. 2015 Mar 2;4(4):e1008866. doi: 10.1080/2162402X.2015.1008866. eCollection 2015 Apr.
Oncoimmunology. 2013 Jan 1;2(1):e22059. doi: 10.4161/onci.22059.
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Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer.自体裂解物脉冲树突状细胞疫苗接种，随后过继转移经疫苗激发的体外共刺激T细胞用于复发性卵巢癌治疗
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