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本文引用的文献

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Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state.人成纤维细胞向心肌样细胞状态的直接重编程。
Stem Cell Reports. 2013 Aug 22;1(3):235-47. doi: 10.1016/j.stemcr.2013.07.005. eCollection 2013.
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Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells.强制聚集和特定因素可从人类胚胎干细胞和诱导多能干细胞中获得高度均匀大小的胚状体和功能性心肌细胞。
Heart Vessels. 2014 Nov;29(6):834-46. doi: 10.1007/s00380-013-0436-9. Epub 2013 Nov 21.
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Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.同基因人多能干细胞对揭示 KCNH2 突变在长 QT 综合征中的作用。
EMBO J. 2013 Dec 11;32(24):3161-75. doi: 10.1038/emboj.2013.240. Epub 2013 Nov 8.
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CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.钙调蛋白依赖性蛋白激酶 II 抑制纠正儿茶酚胺敏感性多形性室性心动过速患者特异性模型中的心律失常表型。
Cell Death Dis. 2013 Oct 10;4(10):e843. doi: 10.1038/cddis.2013.369.
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Cardiovascular disease in Europe: epidemiological update.欧洲心血管疾病：流行病学最新进展。
Eur Heart J. 2013 Oct;34(39):3028-34. doi: 10.1093/eurheartj/eht356. Epub 2013 Sep 7.
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Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.使用源自患者特异性诱导多能干细胞的心肌细胞构建 3 型长 QT 综合征模型。
Int J Cardiol. 2013 Oct 15;168(6):5277-86. doi: 10.1016/j.ijcard.2013.08.015. Epub 2013 Aug 15.
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Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells.用人类诱导多能干细胞衍生的心血管祖细胞重构成去细胞化的小鼠心脏。
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Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells.从尿液来源的细胞中生成非整合的人类诱导多能干细胞库。
PLoS One. 2013 Aug 5;8(8):e70573. doi: 10.1371/journal.pone.0070573. Print 2013.
9
The generation of induced pluripotent stem cells from a patient with KCNH2 G603D, without LQT2 disease associated symptom.从一名没有LQT2疾病相关症状的携带KCNH2 G603D突变的患者身上诱导产生多能干细胞。
J Med Dent Sci. 2013 Mar 1;60(1):17-22.
10
Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering.曲古抑菌素 A 增强人诱导多能干细胞向心肌细胞分化用于心脏组织工程。
Stem Cells Transl Med. 2013 Sep;2(9):715-25. doi: 10.5966/sctm.2012-0161. Epub 2013 Jul 24.

人多能干细胞衍生的心肌细胞作为研究和治疗工具。

Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools.

机构信息

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic.

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic ; ICRC, St. Anne's University Hospital, 60200 Brno, Czech Republic.

出版信息

Biomed Res Int. 2014;2014:512831. doi: 10.1155/2014/512831. Epub 2014 Apr 2.

DOI:10.1155/2014/512831
PMID:24800237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3996932/
Abstract

Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germ layers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).

摘要

人多能干细胞（hPSCs），即胚胎干细胞（ESCs）和诱导多能干细胞（iPSCs），具有无限自我更新的能力，并能分化为所有三个胚层的细胞类型，代表了发育生物学、药物筛选、疾病建模和潜在的细胞替代治疗方面的强大研究工具。为了最大限度地利用这些细胞，需要有能够产生我们感兴趣的细胞类型的高效分化方案。在本工作中，我们旨在专注于 hPSCs 体外分化为功能性心肌细胞的方案，以及在基于患者特异性 iPSC 衍生的心肌细胞（iPSC-CMs）的心脏病建模和药物测试方面的进展。