Institut Curie, CNRS UMR3306, INSERM U1005, Centre Universitaire, Bâtiment 110, 91405 Orsay, France.
Institut Curie, CNRS UMR3306, INSERM U1005, Centre Universitaire, Bâtiment 110, 91405 Orsay, France.
Curr Biol. 2014 May 5;24(9):R351-4. doi: 10.1016/j.cub.2014.03.032.
Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism to generate microtubule identities. As many microtubule functions have direct implications for development and homeostasis of organisms, understanding the molecular functions of tubulin PTMs could provide a more differentiated view on the role of microtubules in both normal and pathological aspects of organism development.
微管是真核细胞骨架中最大的丝状成分。尽管它们的结构高度保守，但微管在细胞中发挥着广泛的不同功能。这种功能多样性是如何实现的仍然是一个悬而未决的问题；然而，最近的进展表明微管蛋白的翻译后修饰（PTMs）是产生微管特性的一种有效机制。由于许多微管功能直接影响生物体的发育和内稳态，因此了解微管 PTM 的分子功能可以为微管在生物体正常和病理发育方面的作用提供更具差异化的视角。
