Proctor D F, Adams G K, Andersen I, Man S F
Ciba Found Symp. 1978(54):219-34. doi: 10.1002/9780470720356.ch11.
Nasal mucociliary clearance was measured in healthy young human subjects and tracheal clearance in the experimental animal under a wide variety of conditions. There is a broad range of clearance rates whether at standard ambient conditions (23 degrees C, 50% relative humidity) or in the face of a number of environmental variables. The degree to which those differences are attributable to the effectiveness of ciliary beating or the character of airway secretions is not known. Studies of tracheobronchial secretions simultaneous with clearance measurement in the anaesthetized dog have not yet provided a definite answer. Variations in upper respiratory defence mechanisms may bear some relationship to the aetiology of small airway disease in the lungs.
在多种条件下，对健康年轻人体受试者的鼻腔黏液纤毛清除功能以及实验动物的气管清除功能进行了测量。无论是在标准环境条件下（23摄氏度，相对湿度50%），还是面对多种环境变量时，清除率都有很大范围。这些差异在多大程度上归因于纤毛摆动的有效性或气道分泌物的特性尚不清楚。在麻醉犬身上同时进行气管支气管分泌物研究和清除测量的研究尚未给出明确答案。上呼吸道防御机制的变化可能与肺部小气道疾病的病因有一定关系。
