Song Changhoon, Wu Hong-Gyun, Chang Hak, Kim Il Han, Ha Sung W
Department of Radiation Oncology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea.
Department of Radiation Oncology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea Institute of Radiation Medicine, Medical Research Center, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
J Radiat Res. 2014 Sep;55(5):912-6. doi: 10.1093/jrr/rru025. Epub 2014 May 6.
The aim of this study was to assess the feasibility and efficacy of high-dose, single-fraction electron beam radiotherapy for therapy-resistant keloids. Before 2010, intractable keloids were treated at our institution with post-operative irradiation of 6-15 Gy in 3-5 fractionations. For convenience and cost effectiveness, we have changed our treatment protocol to high-dose single-fraction radiotherapy. A total of 12 patients with 16 keloid lesions were treated from January 2010 to January 2013 in our department. A 10-Gy dose of electron irradiation was given within 72 h of the surgical excision. The mean follow-up period was 20 months. Treatments were well tolerated, and there was no recurrence in any of the patients. Severe adverse effects were not observed. Surgical excision of the keloid, followed by immediate, single-fraction, high-dose radiotherapy, is both safe and effective in preventing recurrence of therapy-resistant keloids.
本研究的目的是评估大剂量单次分割电子束放射治疗难治性瘢痕疙瘩的可行性和疗效。2010年之前，我院对难治性瘢痕疙瘩采用术后6 - 15 Gy分3 - 5次照射的方法进行治疗。为了方便和具有成本效益，我们将治疗方案改为大剂量单次分割放射治疗。2010年1月至2013年1月，我科共治疗了12例患者的16个瘢痕疙瘩病变。在手术切除后72小时内给予10 Gy的电子照射剂量。平均随访期为20个月。治疗耐受性良好，所有患者均无复发。未观察到严重不良反应。瘢痕疙瘩手术切除后立即进行单次大剂量放射治疗，在预防难治性瘢痕疙瘩复发方面既安全又有效。
