Abi Alireza, Lin Meihua, Pei Hao, Fan Chunhai, Ferapontova Elena E, Zuo Xiaolei
Interdisciplinary Nanoscience Center (iNANO), Science and Technology, ‡Center for DNA Nanotechnology (CDNA) at iNANO, and §Sino-Danish Centre for Education and Research (SDC) at iNANO, Aarhus University , Gustav Wieds Vej 1590-14, DK-8000 Aarhus C, Denmark.
ACS Appl Mater Interfaces. 2014 Jun 11;6(11):8928-31. doi: 10.1021/am501823q. Epub 2014 May 20.
Nanomechanical switching of functional three-dimensional (3D) DNA nanostructures is crucial for nanobiotechnological applications such as nanorobotics or self-regulating sensor and actuator devices. Here, DNA tetrahedral nanostructures self-assembled onto gold electrodes were shown to undergo the electronically addressable nanoswitching due to their mechanical reconfiguration upon external chemical stimuli. That enables construction of robust surface-tethered electronic nanodevices based on 3D DNA tetrahedra. One edge of the tetrahedron contained a partially self-complementary region with a stem-loop hairpin structure, reconfigurable upon hybridization to a complementary DNA (stimulus DNA) sequence. A non-intercalative ferrocene (Fc) redox label was attached to the reconfigurable tetrahedron edge in such a way that reconfiguration of this edge changed the distance between the electrode and Fc.
功能性三维（3D）DNA纳米结构的纳米机械开关对于纳米生物技术应用（如纳米机器人或自调节传感器及致动器装置）至关重要。在此，自组装到金电极上的DNA四面体纳米结构被证明由于在外部化学刺激下的机械重构而经历电子可寻址的纳米开关过程。这使得基于3D DNA四面体构建坚固的表面 tethered 电子纳米器件成为可能。四面体的一条边包含一个具有茎环发夹结构的部分自互补区域，在与互补DNA（刺激DNA）序列杂交时可重构。一种非插入式二茂铁（Fc）氧化还原标记以这样一种方式连接到可重构的四面体边上，即该边的重构改变了电极与Fc之间的距离。
