Yang Chunxue, Kong Alice Pik Shan, Cai Zongwei, Chung Arthur C K
Partner, State Key Laboratory of Environmental and Biological Analysis, and Department of Chemistry, Hong Kong Baptist University, 224, Waterloo Road, Kowloon Tong, Hong Kong, China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China.
Curr Diab Rep. 2017 Nov 2;17(12):132. doi: 10.1007/s11892-017-0966-0.
The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies linking persistent organic pollutants (POPs) to obesity and diabetes and discusses plausible underlying mechanisms.
Increasing evidence suggest that POPs may act as obesogens and diabetogens to promote the development of obesity and diabetes and induce metabolic dysfunction. POPs are synthesized chemicals and are used widely in our daily life. These chemicals are resistant to degradation in chemical or biological processes, which enable them to exist in the environment persistently and to be bio-accumulated in animal and human tissue through the food chain. Increasingly, epidemiologic studies suggest a positive association between POPs and risk of developing diabetes. Understanding the relationship of POPs with obesity and diabetes may shed light on preventive strategies for obesity and diabetes.
肥胖症和糖尿病患病率的不断上升，无法完全用已知风险因素来解释，如不健康饮食、久坐不动的生活方式和家族病史。本综述总结了将持久性有机污染物（POPs）与肥胖症和糖尿病联系起来的现有研究，并讨论了可能的潜在机制。
越来越多的证据表明，持久性有机污染物可能作为致肥胖物和致糖尿病物，促进肥胖症和糖尿病的发展，并诱发代谢功能障碍。持久性有机污染物是合成化学品，在我们的日常生活中广泛使用。这些化学物质在化学或生物过程中抗降解，这使得它们能够在环境中持续存在，并通过食物链在动物和人体组织中生物累积。越来越多的流行病学研究表明，持久性有机污染物与患糖尿病风险之间存在正相关。了解持久性有机污染物与肥胖症和糖尿病的关系，可能有助于揭示肥胖症和糖尿病的预防策略。
