Department of Physics, University of Trento, 38122 Trento, Italy; A.V. Shubnikov Institute of Crystallography RAS, 119333 Moscow, Russia.
Department of Physics, University of Trento, 38122 Trento, Italy; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
Colloids Surf B Biointerfaces. 2014 Jun 1;118:243-8. doi: 10.1016/j.colsurfb.2014.03.053. Epub 2014 Apr 18.
An elegant route for hydroxyapatite (HA) particle synthesis via ionic exchange reaction is reported. Calcium carbonate particles (CaCO3) were recrystallized into HA beads in water solution with phosphate ions. The size of initial CaCO3 particles was controlled upon the synthesis by varying the amount of ethylene glycol (EG) in aqueous solution. The average size of HA beads ranged from 0.6±0.1 to 4.3±1.1μm. Silver nanoparticles were deposited on the surface of HA and CaCO3 particles via silver mirror reaction. Surface enhanced Raman scattering of silver functionalized beads was demonstrated by detecting Rhodamine B. CaCO3 and HA particles have a great potential for design of carrier which can provide diagnostic and therapeutic functions.
通过离子交换反应，报道了一种合成羟基磷灰石（HA）颗粒的优雅途径。碳酸钙颗粒（CaCO3）在水溶液中与磷酸离子重结晶为 HA 珠。通过改变水溶液中乙二醇（EG）的量来控制初始 CaCO3 颗粒的大小。HA 珠的平均粒径范围为 0.6±0.1 至 4.3±1.1μm。银纳米颗粒通过银镜反应沉积在 HA 和 CaCO3 颗粒的表面。通过检测 Rhodamine B 证明了银功能化珠的表面增强拉曼散射。CaCO3 和 HA 颗粒在设计能够提供诊断和治疗功能的载体方面具有很大的潜力。
