IEEE Rev Biomed Eng. 2014;7:73-86. doi: 10.1109/RBME.2013.2295817.
Chronic nonhealing wounds are a major source of morbidity and mortality in bed-ridden and diabetic patients. Monitoring of physical and chemical parameters important in wound healing and remodeling process can be of immense benefit for optimum management of such lesions. Low-cost flexible polymeric and paper-based substrates are attractive platforms for fabrication of such sensors. In this review, we discuss recent advances in flexible physiochemical sensors for chronic wound monitoring. After a brief introduction to wound healing process and commercial wound dressings, we describe various flexible biocompatible substrates that can be used as the base platform for integration of wound monitoring sensors. We will then discuss several fabrication methods that can be utilized to integrate physical and chemical sensors onto such substrates. Finally, we will present physical and chemical sensors developed for monitoring wound microenvironment and outline future development venues.
慢性难愈性创面是卧床和糖尿病患者发病率和死亡率的主要原因。监测创面愈合和重塑过程中重要的理化参数，对于此类病变的最佳管理有巨大的益处。低成本的柔性聚合物和纸基基底是制造此类传感器的理想平台。在这篇综述中，我们讨论了用于慢性创面监测的柔性物理化学传感器的最新进展。在简要介绍创面愈合过程和商业创面敷料后，我们描述了可作为集成创面监测传感器的基础平台使用的各种柔性生物相容性基底。然后，我们将讨论几种可用于将物理和化学传感器集成到这些基底上的制造方法。最后，我们将介绍为监测创面微环境而开发的物理和化学传感器，并概述未来的发展方向。
