School of Social Ecology, University of California, Irvine, California 95616, USA.
Environ Health Perspect. 2011 Dec;119(12):1760-5. doi: 10.1289/ehp.1103729. Epub 2011 Aug 3.
People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities.
Our objective was to estimate historical PFOA exposures and serum concentrations experienced by 45,276 non-occupationally exposed participants in the C8 Health Project who consented to share their residential histories and a 2005-2006 serum PFOA measurement.
We estimated annual PFOA exposure rates for each individual based on predicted calibrated water concentrations and predicted air concentrations using an environmental fate and transport model, individual residential histories, and maps of public water supply networks. We coupled individual exposure estimates with a one-compartment absorption, distribution, metabolism, and excretion (ADME) model to estimate time-dependent serum concentrations.
For all participants (n = 45,276), predicted and observed median serum concentrations in 2005-2006 are 14.2 and 24.3 ppb, respectively [Spearman's rank correlation coefficient (r(s)) = 0.67]. For participants who provided daily public well water consumption rate and who had the same residence and workplace in one of six municipal water districts for 5 years before the serum sample (n = 1,074), predicted and observed median serum concentrations in 2005-2006 are 32.2 and 40.0 ppb, respectively (r(s) = 0.82).
Serum PFOA concentrations predicted by linked exposure and ADME models correlated well with observed 2005-2006 human serum concentrations for C8 Health Project participants. These individualized retrospective exposure and serum estimates are being used in a variety of epidemiologic studies being conducted in this region.
居住或工作在俄亥俄州东部和西弗吉尼亚州西部的人们已经接触到了杜邦华盛顿工厂释放的全氟辛酸 (PFOA)。
我们的目的是估计 45276 名非职业暴露于 C8 健康项目中的参与者的历史 PFOA 暴露量和血清浓度，这些参与者同意分享他们的居住史和 2005-2006 年的血清 PFOA 测量值。
我们根据预测校准的水浓度和使用环境 fate 和 transport 模型、个人居住史和公共供水网络地图预测的空气浓度，为每个个体估计年度 PFOA 暴露率。我们将个体暴露估计值与一个单室吸收、分布、代谢和排泄 (ADME) 模型相结合，以估计时间依赖性血清浓度。
对于所有参与者（n=45276），2005-2006 年预测和观察到的中位数血清浓度分别为 14.2 和 24.3 ppb[Spearman 秩相关系数（r(s)）=0.67]。对于提供每日公共井水消耗量和在血清样本前 5 年在六个市政水区之一有相同住所和工作场所的参与者（n=1074），2005-2006 年预测和观察到的中位数血清浓度分别为 32.2 和 40.0 ppb[r(s)=0.82]。
通过链接暴露和 ADME 模型预测的血清 PFOA 浓度与 C8 健康项目参与者 2005-2006 年的实际血清浓度相关性良好。这些个体化的回顾性暴露和血清估计值正在该地区进行的各种流行病学研究中使用。
