Addiction Department, ULSS 20, Via Germania 20, 37136 Verona, Italy ; Department of Neurological and Movement Sciences, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Department of Neurological and Movement Sciences, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Behav Neurol. 2014;2014:815215. doi: 10.1155/2014/815215. Epub 2014 Jan 23.
Drug addiction can be a devastating and chronic relapsing disorder with social, psychological, and physical consequences, and more effective treatment options are needed. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that has been assessed in a growing number of studies for its therapeutic potential in treating addiction. This review paper offers an overview on the current state of clinical research in treating drug addiction with rTMS. Because of the limited research in this area, all studies (including case reports) that evaluated the therapeutic use of rTMS in nicotine, alcohol, or illicit drug addiction were included in this review. Papers published prior to December 2012 were found through an NCBI PubMed search. A total of eleven studies were identified that met review criteria. There is nascent evidence that rTMS could be effective in reducing cocaine craving and nicotine and alcohol craving and consumption and might represent a potential therapeutic tool for treating addiction. Further studies are needed to identify the optimal parameters of stimulation for the most effective treatment of drug addiction, to improve our comprehension of the treatment neurophysiological effects, and to conduct rigorous, controlled efficacy studies with adequate power.
药物成瘾是一种具有社会心理和生理后果的破坏性和慢性复发性疾病，需要更有效的治疗选择。重复经颅磁刺激（rTMS）是一种非侵入性的脑刺激技术，越来越多的研究评估了其在治疗成瘾方面的治疗潜力。这篇综述论文概述了 rTMS 治疗药物成瘾的临床研究现状。由于该领域的研究有限，本综述纳入了所有评估 rTMS 治疗尼古丁、酒精或非法药物成瘾的治疗用途的研究（包括病例报告）。在 NCBI PubMed 上搜索了 2012 年 12 月之前发表的论文。共确定了 11 项符合审查标准的研究。有初步证据表明 rTMS 可能有效减少可卡因渴求、尼古丁和酒精渴求以及消费，可能代表治疗成瘾的一种潜在治疗工具。需要进一步的研究来确定刺激的最佳参数，以实现药物成瘾的最有效治疗，提高我们对治疗神经生理效应的理解，并进行具有足够效力的严格对照疗效研究。
