Bol V, Grégoire V
Center for Molecular Imaging, Radiotherapy and Oncology, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain (UCL), B1.5407 Avenue Hippocrate, No. 54-55, 1200 Brussels, Belgium.
Biomed Res Int. 2014;2014:696028. doi: 10.1155/2014/696028. Epub 2014 Apr 3.
Although development of head and neck squamous cell carcinomas (HNSCCs) is commonly linked to the consumption of tobacco and alcohol, a link between human papillomavirus (HPV) infection and a subgroup of head and neck cancers has been established. These HPV-positive tumors represent a distinct biological entity with overexpression of viral oncoproteins E6 and E7. It has been shown in several clinical studies that HPV-positive HNSCCs have a more favorable outcome and greater response to radiotherapy. The reason for improved prognosis of HPV-related HNSCC remains speculative, but it could be owned to multiple factors. One hypothesis is that HPV-positive cells are intrinsically more sensitive to standard therapies and thus respond better to treatment. Another possibility is that HPV-positive tumors uniquely express viral proteins that induce an immune response during therapy that helps clear tumors and prevents recurrence. Here, we will review current evidence for the biological basis of increased radiosensitivity in HPV-positive HNSCC.
虽然头颈部鳞状细胞癌（HNSCC）的发生通常与烟草和酒精的摄入有关，但人类乳头瘤病毒（HPV）感染与一部分头颈癌之间的联系已得到证实。这些HPV阳性肿瘤代表了一种独特的生物学实体，具有病毒癌蛋白E6和E7的过表达。多项临床研究表明，HPV阳性的HNSCC预后更佳，对放疗的反应也更好。HPV相关HNSCC预后改善的原因仍属推测，但可能是多种因素所致。一种假说认为，HPV阳性细胞对标准疗法具有内在的更高敏感性，因此对治疗反应更好。另一种可能性是，HPV阳性肿瘤独特地表达病毒蛋白，这些蛋白在治疗期间引发免疫反应，有助于清除肿瘤并防止复发。在此，我们将综述目前关于HPV阳性HNSCC放射敏感性增加的生物学基础的证据。
