Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Br J Dermatol. 2014 Nov;171(5):1084-90. doi: 10.1111/bjd.13093. Epub 2014 Oct 6.
Vitiligo has a significant psychological impact which needs to be evaluated separately from the extent of depigmentation. We have developed a vitiligo-specific quality-of-life (QoL) instrument, Vitiligo Impact Scale-22 (VIS-22) for this purpose.
To study the measurement properties of VIS-22 and compare it with the Dermatology Life Quality Index (DLQI) and Skindex-16.
Item-reduction analysis was used to reduce the number of items in the original VIS from 27 to 22. The 5-point Physician's Global Assessment (PGA) was used to evaluate the QoL followed by a Visual Analogue Scale (VAS) to assess patient-perceived severity. VIS-22, DLQI and Skindex-16 were self-administered. The validity of the VIS-22 was assessed in 161 patients, reliability in 69 patients and responsiveness in 72 patients and compared with DLQI and Skindex-16.
Criterion validity was shown by strong correlation of VIS-22 with VAS (r = 0·7076). Convergent validity was evidenced by strong correlations with DLQI (r = 0·71) and Skindex-16 (r = 0·72). Known-groups validity was demonstrated by significantly higher scores in females, those with less education, patients with progressive disease and patients with vitiligo compared with controls (P < 0·001). Reliability was shown by excellent correlation of the scores between baseline and 2 weeks (r = 0·9053). VIS-22 was found to be responsive with scores at 12 weeks moving parallel to scores on VAS. Similar trends were noted with DLQI and Skindex-16.
VIS-22 is a valid, reliable and responsive QoL instrument. It is comparable to DLQI and Skindex-16 in its measurement properties, while being specific to the needs of patients with vitiligo.
白癜风对患者心理有重大影响，需要单独评估，与色素脱失程度分开评估。为此，我们开发了一种专门用于评估白癜风患者生活质量的工具，即白癜风患者生活质量量表 22 项（VIS-22）。
研究 VIS-22 的测量特性，并与皮肤病生活质量指数（DLQI）和 Skindex-16 进行比较。
采用项目删减分析将原始 VIS 量表的 27 个条目减少至 22 个条目。采用 5 分制医生总体评估（PGA）评估生活质量，随后采用视觉模拟评分（VAS）评估患者感知的严重程度。VIS-22、DLQI 和 Skindex-16 均采用自我报告的方式进行评估。在 161 例患者中评估 VIS-22 的有效性，在 69 例患者中评估可靠性，在 72 例患者中评估反应性，并与 DLQI 和 Skindex-16 进行比较。
量效关系研究表明，VIS-22 与 VAS 具有高度相关性（r=0.7076），提示具有较好的效标效度。与 DLQI（r=0.71）和 Skindex-16（r=0.72）的相关性较强，提示具有较好的聚合效度。与女性、教育程度较低、疾病进展患者和白癜风患者的生活质量评分显著高于对照组（P<0.001），提示具有较好的区分效度。基线和 2 周时评分之间具有极好的相关性（r=0.9053），提示具有较好的可靠性。12 周时评分与 VAS 评分平行移动，提示具有较好的反应性。DLQI 和 Skindex-16 也显示出类似的趋势。
VIS-22 是一种有效、可靠和敏感的生活质量评估工具。它在测量特性方面与 DLQI 和 Skindex-16 相当，同时也专门针对白癜风患者的需求。
