Yoshimura Naoki, Oguchi Tomohiko, Yokoyama Hitoshi, Funahashi Yasuhito, Yoshikawa Satoru, Sugino Yoshio, Kawamorita Naoki, Kashyap Mahendra P, Chancellor Michael B, Tyagi Pradeep, Ogawa Teruyuki
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Int J Urol. 2014 Apr;21 Suppl 1(0 1):18-25. doi: 10.1111/iju.12308.
Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.
膀胱疼痛综合征/间质性膀胱炎是一种伴有下尿路症状（如膀胱疼痛和尿频）的疾病，这会严重损害患者的生活质量。极度的疼痛和尿频往往难以治疗。尽管膀胱疼痛综合征/间质性膀胱炎的病因仍不明确，但越来越多的证据表明，神经源性膀胱炎症和尿路上皮功能障碍导致的传入神经兴奋性过高对症状发展的病理生理基础至关重要。对病理生理学的进一步研究将有助于有效治疗膀胱疼痛综合征/间质性膀胱炎患者。
