Division of Pediatric General and Thoracic Surgery, Department of Surgery, The Hospital for Sick Children, University of Toronto , Toronto, ON , Canada.
Front Pediatr. 2014 Apr 29;2:36. doi: 10.3389/fped.2014.00036. eCollection 2014.
In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia (CDH) has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this anomaly in the laboratory has resulted in the discovery of many important genetic, epigenetic, and other molecular contributors to this condition. In this review, the most commonly used and newly devised animal models of CDH are presented to familiarize the reader with the latest innovations in the basic sciences.
近几十年来，对先天性膈疝 (CDH) 的发育缺陷和病理生理学基础的新研究揭示了开发创新疗法的机会。重要的是，使用动物模型在实验室中代表这种异常，导致发现了许多对这种情况有重要贡献的遗传、表观遗传和其他分子因素。在这篇综述中，介绍了最常用和新设计的 CDH 动物模型，以使读者熟悉基础科学的最新创新。
