Knappke Christiane E I, Grupe Sabine, Gärtner Dominik, Corpet Martin, Gosmini Corinne, Jacobi von Wangelin Axel
Chemistry Research Laboratory, University of Oxford (U.K.).
Chemistry. 2014 Jun 2;20(23):6828-42. doi: 10.1002/chem.201402302. Epub 2014 May 13.
Reductive cross-electrophile coupling reactions have recently been developed to a versatile and sustainable synthetic tool for selective C-C bond formation. The employment of cheap and abundant electrophiles avoids the pre-formation and handling of organometallic reagents. In situ reductive coupling is effected in the presence of a transition-metal catalyst (Ni, Co, Pd, Fe) and a suitable metallic reductant (Mn, Zn, Mg). This Concept article assesses the current state of the art and summarizes recent protocols with various combinations of alkyl, alkenyl, allyl, and aryl reagents and highlights key mechanistic studies.
还原性交叉亲电试剂偶联反应最近已发展成为一种用于选择性碳-碳键形成的通用且可持续的合成工具。使用廉价且丰富的亲电试剂避免了有机金属试剂的预先制备和处理。原位还原偶联在过渡金属催化剂（镍、钴、钯、铁）和合适的金属还原剂（锰、锌、镁）存在下进行。这篇概念文章评估了当前的技术水平，并总结了最近使用烷基、烯基、烯丙基和芳基试剂的各种组合的方法，同时突出了关键的机理研究。
