较高的25(OH)D2与较低的25(OH)D3和1,25(OH)2D3相关。
Higher 25(OH)D2 is associated with lower 25(OH)D3 and 1,25(OH)2D3.
作者信息
Swanson Christine M, Nielson Carrie M, Shrestha Smriti, Lee Christine G, Barrett-Connor Elizabeth, Jans Ivo, Cauley Jane A, Boonen Steven, Bouillon Roger, Vanderschueren Dirk, Orwoll Eric S
机构信息
Division of Endocrinology (C.M.S., C.G.L., E.S.O.), Bone and Mineral Unit (C.M.S., C.M.N., S.S., C.G.L., E.S.O.), and Department of Public Health and Preventive Medicine (C.M.N.), Oregon Health & Science University, Portland, Oregon 97239; Research Service (C.G.L.), Portland Veterans Affairs Medical Center, Portland, Oregon 97239; Division of Epidemiology (E.B.-C.), Department of Family & Preventive Medicine, University California San Diego, La Jolla, California 92093-0607; Laboratory of Diagnostic Medicine (I.J., D.V.), KU Leuven, University of Leuven, 3000 Leuven, Belgium; Department of Epidemiology (J.A.C.), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261; and Division of Geriatric Medicine and Centre for Metabolic Bone Diseases (S.B.), and Laboratory of Clinical and Experimental Endocrinology (R.B., D.V.), KU Leuven, University of Leuven, 3000 Leuven, Belgium.
出版信息
J Clin Endocrinol Metab. 2014 Aug;99(8):2736-44. doi: 10.1210/jc.2014-1069. Epub 2014 May 14.
CONTEXT
Despite common use of supplemental vitamin D2 in clinical practice, the associations of serum vitamin D2 concentrations with other vitamin D metabolites and total vitamin D are unclear.
OBJECTIVE
The aim of the study was to measure vitamin D2 and D3 levels and examine their associations with each other and with total vitamin D.
DESIGN
We performed a cross-sectional analysis of 679 randomly selected participants from the Osteoporotic Fractures in Men Study. 25-Hydroxyvitamin D2 [25(OH)D2], 25(OH)D3, 1,25-dihydroxyvitamin D2 [1,25(OH)2D2], and 1,25(OH)2D3 were measured using liquid chromatography-tandem mass spectrometry and were summed to obtain total 25(OH)D and 1,25(OH)2D. Associations between all metabolites (D2, D3, and total levels) were examined using Wilcoxon rank-sum tests and Spearman correlations.
RESULTS
25(OH)D2 and 1,25(OH)2D2 were detectable in 189 (27.8%) and 178 (26.2%) of the men, respectively. Higher 25(OH)D2 levels did not correlate with higher total 25(OH)D (r = 0.10; P = .17), although median total 25(OH)D was slightly higher in those with detectable vs undetectable 25(OH)D2 (25.8 vs 24.3 ng/mL; P < .001). 25(OH)D2 was not positively associated with total 1,25(OH)2D levels (r = -0.11; P = .13), and median 1,25(OH)2D level was not higher in those with detectable vs undetectable 25(OH)D2. Higher 25(OH)D2 was associated with lower 25(OH)D3 (r = -0.35; P < .001) and 1,25(OH)2D3 (r = -0.32; P < .001), with median levels of both D3 metabolites 18-35% higher when D2 metabolites were undetectable.
CONCLUSIONS
In a cohort of older men, 25(OH)D2 is associated with lower levels of 25(OH)D3 and 1,25(OH)2D3, suggesting that vitamin D2 may decrease the availability of D3 and may not increase calcitriol levels.
背景
尽管临床实践中普遍使用维生素D2补充剂，但血清维生素D2浓度与其他维生素D代谢物及总维生素D之间的关联尚不清楚。
目的
本研究旨在测量维生素D2和D3水平，并检验它们之间以及与总维生素D的关联。
设计
我们对从男性骨质疏松性骨折研究中随机选取的679名参与者进行了横断面分析。使用液相色谱 - 串联质谱法测量25 - 羟基维生素D2 [25(OH)D2]、25(OH)D3、1,25 - 二羟基维生素D2 [1,25(OH)2D2]和1,25(OH)2D3，并将其相加得到总25(OH)D和1,25(OH)2D。使用Wilcoxon秩和检验和Spearman相关性检验来研究所有代谢物（D2、D3和总水平）之间的关联。
结果
分别在189名（27.8%）和178名（26.2%）男性中检测到25(OH)D2和1,25(OH)2D2。较高的25(OH)D2水平与较高的总25(OH)D不相关（r = 0.10；P = 0.17），尽管可检测到25(OH)D2的参与者的总25(OH)D中位数略高于未检测到的参与者（25.8对24.3 ng/mL；P < 0.001）。25(OH)D2与总1,25(OH)2D水平无正相关（r = -
0.11；P = 0.13），并且可检测到25(OH)D2的参与者的1,25(OH)2D中位数水平并不更高。较高的25(OH)D2与较低的25(OH)D3（r =
- 0.35；P < 0.001）和1,25(OH)2D3（r = - 0.32；P < 0.001）相关，当未检测到D2代谢物时，两种D3代谢物的中位数水平高18 - 35%。
结论
在一组老年男性中，25(OH)D2与较低水平的25(OH)D3和1,25(OH)2D3相关，这表明维生素D2可能会降低D3的可用性，并且可能不会增加骨化三醇水平。
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