Reed Carrie, Bruden Dana, Byrd Kathy K, Veguilla Vic, Bruce Michael, Hurlburt Debby, Wang David, Holiday Crystal, Hancock Kathy, Ortiz Justin R, Klejka Joe, Katz Jacqueline M, Uyeki Timothy M
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Influenza Other Respir Viruses. 2014 Sep;8(5):516-23. doi: 10.1111/irv.12253. Epub 2014 May 14.
Highly pathogenic avian influenza A (HPAI) H5N1 viruses have infected poultry and wild birds on three continents with more than 600 reported human cases (59% mortality) since 2003. Wild aquatic birds are the natural reservoir for avian influenza A viruses, and migratory birds have been documented with HPAI H5N1 virus infection. Since 2005, clade 2.2 HPAI H5N1 viruses have spread from Asia to many countries.
We conducted a cross-sectional seroepidemiological survey in Anchorage and western Alaska to identify possible behaviors associated with migratory bird exposure and measure seropositivity to HPAI H5N1.
We enrolled rural subsistence bird hunters and their families, urban sport hunters, wildlife biologists, and a comparison group without bird contact. We interviewed participants regarding their exposures to wild birds and collected blood to perform serologic testing for antibodies against a clade 2.2 HPAI H5N1 virus strain.
Hunters and wildlife biologists reported exposures to wild migratory birds that may confer risk of infection with avian influenza A viruses, although none of the 916 participants had evidence of seropositivity to HPAI H5N1.
We characterized wild bird contact among Alaskans and behaviors that may influence risk of infection with avian influenza A viruses. Such knowledge can inform surveillance and risk communication surrounding HPAI H5N1 and other influenza viruses in a population with exposure to wild birds at a crossroads of intercontinental migratory flyways.
高致病性甲型禽流感（HPAI）H5N1病毒已在三大洲感染家禽和野生鸟类，自2003年以来报告了600多例人类病例（死亡率为59%）。野生水鸟是甲型禽流感病毒的天然宿主，有记录表明候鸟感染了HPAI H5N1病毒。自2005年以来，2.2分支HPAI H5N1病毒已从亚洲传播到许多国家。
我们在安克雷奇和阿拉斯加西部进行了一项横断面血清流行病学调查，以确定与候鸟接触相关的可能行为，并测量对HPAI H5N1的血清阳性率。
我们招募了以捕猎为生的农村鸟类猎人及其家人、城市运动猎人、野生动物生物学家，以及一个没有鸟类接触的对照组。我们就参与者与野生鸟类的接触情况进行了访谈，并采集血液进行针对2.2分支HPAI H5N1病毒株抗体的血清学检测。
猎人及野生动物生物学家报告了与野生候鸟的接触，这可能带来感染甲型禽流感病毒的风险，尽管916名参与者中无人有HPAI H5N1血清阳性的证据。
我们描述了阿拉斯加人与野生鸟类的接触情况以及可能影响感染甲型禽流感病毒风险的行为。这些知识可为在洲际迁徙路线交汇处接触野生鸟类的人群中围绕HPAI H5N1及其他流感病毒的监测和风险沟通提供信息。
