Roato Ilaria
Ilaria Roato, CeRMS, AO Città della Salute e della Scienza di Torino, Department of Medical Science, University of Turin, 10126 Torino, Italy.
World J Clin Oncol. 2014 May 10;5(2):149-55. doi: 10.5306/wjco.v5.i2.149.
30%-40% of patients with non-small cell lung cancer develop bone metastases during the course of their disease. Lung cancer cells find a favorable soil in the bone microenvironment due to factors released by the bone matrix, the immune system cells, and the same cancer cells. Many aspects of the cross-talk among lung tumor cells, the immune system, and bone cells are not clear, but this review aims to summarize the recent findings in this field, with particular attention to studies conducted to identify biomarkers for early detection of lung cancer bone metastases.
30%-40%的非小细胞肺癌患者在病程中会发生骨转移。由于骨基质、免疫系统细胞以及癌细胞自身释放的因子，肺癌细胞在骨微环境中找到了适宜的土壤。肺肿瘤细胞、免疫系统和骨细胞之间相互作用的许多方面尚不清楚，但本综述旨在总结该领域的最新研究结果，尤其关注为识别肺癌骨转移早期检测生物标志物而开展的研究。
