Müller-Stöver I, Tintelnot K, Richter J, Häussinger D
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland,
Internist (Berl). 2014 Aug;55(8):976-80. doi: 10.1007/s00108-014-3517-7.
A 55-year-old woman presented 18 months after a trip to Ecuador with night sweat, malaise, and an unclear lesion of the lung. Computed tomography of the lung showed a nodular lesion of 14 mm. Antibodies against Histoplasma capsulatum were detected in the complement fixation text (CFT) and IgG western blot. Re-examination of a formalin fixed paraffin embedded (FFPE) lung-biopsy revealed yeasts after silver staining, compatible with H. capsulatum , which was verified by extraction and amplification of DNA from FFPE. After therapy with itraconazole 400 mg/day, the patient showed an uneventful clinical recovery without regression of the lung lesion. The serological follow-up examination after 17 months showed CFT without pathological findings.
一名55岁女性在前往厄瓜多尔旅行18个月后出现盗汗、不适和肺部不明病变。肺部计算机断层扫描显示一个14毫米的结节性病变。在补体结合试验（CFT）和IgG免疫印迹中检测到针对荚膜组织胞浆菌的抗体。对福尔马林固定石蜡包埋（FFPE）的肺活检标本重新检查，银染色后发现酵母，与荚膜组织胞浆菌相符，通过从FFPE中提取和扩增DNA进行了验证。在用伊曲康唑400毫克/天治疗后，患者临床恢复顺利，但肺部病变未消退。17个月后的血清学随访检查显示CFT无病理结果。
