Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of sciences, Shanghai, 200031, China; Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
Small. 2014 Sep 24;10(18):3603-11. doi: 10.1002/smll.201303635. Epub 2014 May 15.
Nanoparticles have shown great potential in biological and biomedical applications due to their distinct physical and chemical properties. In the meanwhile, the biosafety of nanoparticles has also raised intense concerns worldwide. To address such concerns, great efforts have been made to examine short-term effects of nanoparticles on cell survival and proliferation. More recently, exploration of long-term effects of nanomaterials, particularly those with promising biomedical applications in vivo, has aroused significant interest. For example, gold nanoparticles (AuNPs) are generally considered non-toxic to cell growth, whereas recent studies suggest that AuNPs might have long-term effects on cellular metabolism and energy homeostasis. In this Review, recent advances in this direction are summarized. Further, possible mechanisms under which nanoparticles regulate metabolic signaling pathways, potential long-term effects on cellular anabolic or catabolic processes, and their implications in human health and metabolic disorders are discussed.
纳米粒子由于其独特的物理和化学性质，在生物和生物医学应用中显示出巨大的潜力。与此同时，纳米粒子的生物安全性也引起了全世界的强烈关注。为了解决这些担忧，人们做出了巨大的努力来研究纳米粒子对细胞存活和增殖的短期影响。最近，对纳米材料的长期影响的探索，特别是那些在体内具有有前途的生物医学应用的纳米材料，引起了极大的兴趣。例如，金纳米粒子（AuNPs）通常被认为对细胞生长无毒，而最近的研究表明，AuNPs 可能对细胞代谢和能量稳态有长期影响。在这篇综述中，总结了这方面的最新进展。此外，还讨论了纳米粒子调节代谢信号通路的可能机制、对细胞合成代谢或分解代谢过程的潜在长期影响，以及它们对人类健康和代谢紊乱的影响。
