Enzyme immunoassay of progesterone receptor in cancerous and normal endometrial tissue. A comparison with dextran coated charcoal method.

Enzyme immunoassay (EIA) was compared with the dextran-coated charcoal method and Scatchard analysis for the measurement of progesterone receptor (PgR) in cancerous and normal endometrial samples. A highly significant correlation was obtained between the two assays in both types of tissue (rs = 0.77 and 0.91, respectively; p less than 0.001). The measurable amount of PgR was usually higher with EIA (mean increase 90 and 100 per cent, respectively). EIA is suggested to be a suitable method for PgR measurement in endometrial tissue (normal and cancerous) and can also be used for analysis of PgR in the nuclear fraction.