Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Evid Based Complement Alternat Med. 2014;2014:365742. doi: 10.1155/2014/365742. Epub 2014 Apr 16.
Background. We for the first time examined the effects of a multiherb formula containing Crataegus pinnatifida (1 g daily), Alisma orientalis, Stigma maydis, Ganoderma lucidum, Polygonum multiflorum, and Morus alba on plasma lipid and glucose levels in Chinese patients with dyslipidemia. Methods. In this randomized, double-blind, placebo-controlled study, 42 patients were randomized at a ratio of 1 : 1 to receive the herbal formula or placebo for 12 weeks and 40 patients completed the study. Lipid profiles, glucose, glycated haemoglobin (HbA1c), and laboratory safety parameters were performed before and after treatment. Results. The difference in the changes in low-density lipoprotein cholesterol (LDL-C) levels between placebo and active treatment (-9%) was significantly (P < 0.05) better with active treatment. HbA1c levels significantly decreased by -3.9% in the active treatment group, but the change was not significantly different from that with placebo (-1.1%) (P = 0.098). There were no apparent adverse effects or changes in laboratory safety parameters with either treatment. Conclusions. The multiherb formula had mild beneficial effects on plasma LDL-C after 12-weeks treatment in subjects with dyslipidemia without any noticeable adverse effects.
我们首次研究了含有山楂（每日 1g）、泽泻、玉米须、灵芝、何首乌和桑白皮的多草药配方对血脂异常中国患者的血脂和血糖水平的影响。
在这项随机、双盲、安慰剂对照研究中，42 名患者按 1:1 的比例随机分为接受草药配方或安慰剂治疗 12 周，40 名患者完成了研究。在治疗前后进行了血脂谱、血糖、糖化血红蛋白（HbA1c）和实验室安全参数的检测。
与安慰剂相比，低密度脂蛋白胆固醇（LDL-C）水平变化的差异在活性治疗组中（-9%）明显更好（P<0.05）。活性治疗组的 HbA1c 水平显著下降了-3.9%，但与安慰剂相比无显著差异（-1.1%）（P=0.098）。两种治疗均无明显不良反应或实验室安全参数变化。
在血脂异常患者中，多草药配方治疗 12 周后对血浆 LDL-C 有轻微的有益作用，无明显不良反应。
