Kovacic Katja, Li B U K
Center for Pediatric Neurogastroenterology, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA,
Curr Gastroenterol Rep. 2014;16(7):395. doi: 10.1007/s11894-014-0395-z.
Chronic nausea is an increasingly acknowledged complaint in children. It is commonly encountered in association with functional gastrointestinal (GI) disorders but can also occur in isolation. As such, there is no pediatric diagnostic classification for chronic idiopathic nausea. The pathophysiology appears complex, from foregut motor and sensory disturbances to autonomic imbalance and CNS influences. Also, there is scarcity of specific treatments that target this highly bothersome symptom. Treatment is mainly empiric or aimed at other functional complaints. Our retrospective data indicate a high prevalence of comorbid conditions in children with chronic nausea. These include migraines, autonomic disturbances, sleep problems, fatigue, and anxiety. Identifying specific features and targeting these therapeutically may be essential for improved treatment outcomes.
慢性恶心在儿童中是一种越来越受到认可的病症。它通常与功能性胃肠疾病相关，但也可能单独出现。因此，目前尚无针对慢性特发性恶心的儿科诊断分类。其病理生理学似乎很复杂，从前肠运动和感觉障碍到自主神经失衡以及中枢神经系统的影响。此外，针对这种令人极为困扰的症状的特异性治疗方法也很匮乏。治疗主要是经验性的，或针对其他功能性病症。我们的回顾性数据表明，慢性恶心儿童中合并症的患病率很高。这些合并症包括偏头痛、自主神经紊乱、睡眠问题、疲劳和焦虑。识别特定特征并针对这些特征进行治疗可能对改善治疗效果至关重要。
