Yamamoto Yasuhiko, Yamamoto Hiroshi
Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
J Diabetes Investig. 2012 Mar 28;3(2):107-14. doi: 10.1111/j.2040-1124.2011.00191.x.
Diabetic vascular complications, such as cardiovascular disease, stroke and microangiopathy, lead to high rates of morbidity and mortality in patients with long-term diabetes. Extensive intracellular and extracellular formation of advanced glycation end-products (AGE) is considered a causative factor in vascular injuries in diabetes. Receptor-dependent mechanisms are involved in AGE-induced cellular dysfunction and tissue damage. The receptor for AGE (RAGE), originally an AGE-binding receptor, is now recognized as a member of pattern-recognition receptors and a pro-inflammatory molecular device that mediates danger signals to the body. Previous animal studies have shown RAGE dependent of diabetic vascular injuries. Prophylactic and therapeutic strategies focusing on RAGE and its ligand axis will be of great importance in conquering diabetic vascular complications. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00191.x, 2012).
糖尿病血管并发症，如心血管疾病、中风和微血管病变，会导致长期糖尿病患者出现高发病率和死亡率。晚期糖基化终产物（AGE）在细胞内和细胞外大量形成被认为是糖尿病血管损伤的一个致病因素。受体依赖性机制参与了AGE诱导的细胞功能障碍和组织损伤。AGE受体（RAGE）最初是一种AGE结合受体，现在被认为是模式识别受体的一员，也是一种促炎分子装置，可将危险信号传递给身体。先前的动物研究表明RAGE与糖尿病血管损伤有关。针对RAGE及其配体轴的预防和治疗策略对于攻克糖尿病血管并发症将具有重要意义。（《糖尿病研究杂志》，doi: 10.1111/j.2040-1124.2011.00191.x，2012年）
