Abbasi Shaghayegh, Karimi Kiana, Hossein Moridpour Amir, Musazadeh Vali, Faghfouri Amir Hossein, Jozi Hannane
Department of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran.
Front Nutr. 2023 Sep 7;10:1179089. doi: 10.3389/fnut.2023.1179089. eCollection 2023.
The findings of randomized controlled trials (RCTs) regarding the effect of flaxseed on adipokine concentrations are conflicting. Therefore, the present meta-analysis was conducted to provide definite and conclusive results.
Systematically, Scopus, Embase, PubMed, Web of Science databases, and Google Scholar were searched for relevant literature published up to December 2022. Based on random-effect models, standard mean differences (SMDs) were calculated for net changes in adipokine concentrations.
Overall, 13 RCTs (15 arms) were eligible to be included. The results indicated that leptin was significantly reduced after the intervention with flaxseed supplement (SMD = -0.69, 95% CI: -1.37, -0.01; = 0.048; = 92.0%, < 0.001). In addition, flaxseed supplements had no considerable effect on plasma adiponectin (SMD = 0.52, 95% CI: -0.20, 1.25, = 0.159; = 92.0%, < 0.001).
Flaxseed significantly improves leptin but does not affect adiponectin concentrations. Additional future well-designed trials are required to further assess the potential benefits of flaxseed on adipokines in humans.
关于亚麻籽对脂肪因子浓度影响的随机对照试验（RCT）结果相互矛盾。因此，进行了本荟萃分析以提供明确和确凿的结果。
系统检索了Scopus、Embase、PubMed、Web of Science数据库以及谷歌学术，以查找截至2022年12月发表的相关文献。基于随机效应模型，计算了脂肪因子浓度净变化的标准平均差（SMD）。
总体而言，13项随机对照试验（15个组）符合纳入标准。结果表明，补充亚麻籽干预后瘦素显著降低（SMD = -0.69，95%CI：-1.37，-0.01；P = 0.048；I² = 92.0%，P < 0.001）。此外，亚麻籽补充剂对血浆脂联素没有显著影响（SMD = 0.52，95%CI：-0.20，1.25，P = 0.159；I² = 92.0%，P < 0.001）。
亚麻籽能显著改善瘦素水平，但不影响脂联素浓度。未来还需要更多精心设计的试验来进一步评估亚麻籽对人体脂肪因子的潜在益处。
