Section of Liaison Psychiatry & Palliative Medicine.
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo.
J Diabetes Investig. 2012 Jun 6;3(3):325-30. doi: 10.1111/j.2040-1124.2011.00170.x.
Aims/Introduction: It has been suggested that type 2 diabetes is associated with cognitive impairment. We investigated the neuropsychological profile of inpatients with poorly controlled type 2 diabetes and assessed the effects of clinical factors on neuropsychological functions.
Forty-two patients with type 2 diabetes and 32 non diabetic control subjects were matched for age, sex ratio, and level of education. Attention & working memory, processing speed, verbal memory, visuospatial memory, visuoconstruction, and executive function were tested. Information about physical function, alcohol use, hypertension, dyslipidemia, and myocardial infarction was retrieved from personal interviews and medical records.
Diabetic patients demonstrated mild cognitive deterioration in attention & working memory, processing speed, verbal memory, and executive function. In particular, neuropsychological decline became prominent when tasks related with speed and verbal stimuli became unstructured and complex. Age was significantly associated with the majority of neuropsychological tests, whereas tasks dealing with working memory and executive function were associated with age only in the diabetic group. Duration of diabetes was associated with Backward Digit Span.
Accelerated aging had a major influence on cognitive decline in the diabetic group, whereas diminished performance in working memory and executive function might have been more related to diabetes-related cognitive impairment. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00170.x, 2011).
目的/引言：有研究表明，2 型糖尿病与认知障碍有关。我们研究了血糖控制不佳的 2 型糖尿病住院患者的神经心理学特征，并评估了临床因素对神经心理学功能的影响。
42 例 2 型糖尿病患者和 32 名非糖尿病对照者按年龄、性别比和受教育程度匹配。我们测试了注意力和工作记忆、处理速度、言语记忆、视空间记忆、视空间构建和执行功能。通过个人访谈和病历获取有关身体功能、饮酒、高血压、血脂异常和心肌梗死的信息。
糖尿病患者在注意力和工作记忆、处理速度、言语记忆和执行功能方面表现出轻度认知功能下降。特别是当与速度和言语刺激相关的任务变得不规范和复杂时，神经心理学的下降变得更加明显。年龄与大多数神经心理学测试显著相关，而与工作记忆和执行功能相关的任务仅在糖尿病组中与年龄相关。糖尿病病程与倒背数字广度相关。
在糖尿病组中，加速衰老对认知能力下降有重大影响，而工作记忆和执行功能的下降可能与糖尿病相关的认知障碍更为相关。（J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00170.x, 2011）。
