CopA3肽可预防紫外线诱导的人皮肤成纤维细胞中I型前胶原的抑制及基质金属蛋白酶-1的诱导。
CopA3 peptide prevents ultraviolet-induced inhibition of type-I procollagen and induction of matrix metalloproteinase-1 in human skin fibroblasts.
作者信息
Kim Dong-Hee, Kim Han-Hyuk, Kim Hyeon-Jeong, Jung Hyun-Gug, Yu Jae-Myo, Lee Eun-Su, Cho Yong-Hun, Kim Dong-In, An Bong-Jeun
机构信息
Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan 712-260, Korea.
Advanced Medical Fusion Textile Center, Gyeongbuk Technopark Foundation, Gyeongsan 712-210, Korea.
出版信息
Molecules. 2014 May 20;19(5):6407-14. doi: 10.3390/molecules19056407.
Ultraviolet (UV) exposure is well-known to induce premature aging, which is mediated by matrix metalloproteinase-1 (MMP-1) activity. A 9-mer peptide, CopA3 (CopA3) was synthesized from a natural peptide, coprisin, which is isolated from the dung beetle Copris tripartitus. As part of our continuing search for novel bioactive natural products, CopA3 was investigated for its in vitro anti-skin photoaging activity. UV-induced inhibition of type-I procollagen and induction of MMP-1 were partially prevented in human skin fibroblasts by CopA3 peptide in a dose-dependent manner. At a concentration of 25 μM, CopA3 nearly completely inhibited MMP-1 expression. These results suggest that CopA3, an insect peptide, is a potential candidate for the prevention and treatment of skin aging.
众所周知，紫外线（UV）照射会导致皮肤过早衰老，这一过程由基质金属蛋白酶-1（MMP-1）的活性介导。一种9肽CopA3是由从粪金龟Copris tripartitus中分离出的天然肽coprisin合成而来。作为我们持续寻找新型生物活性天然产物的一部分，对CopA3的体外抗皮肤光老化活性进行了研究。CopA3肽以剂量依赖的方式部分阻止了紫外线诱导的人皮肤成纤维细胞中I型前胶原的抑制和MMP-1的诱导。在浓度为25μM时，CopA3几乎完全抑制了MMP-1的表达。这些结果表明，昆虫肽CopA3是预防和治疗皮肤衰老的潜在候选物。
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