Yang Hai-Chun, Liu Shao-Jun, Fogo Agnes B
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tenn., USA.
Nephron Exp Nephrol. 2014;126(2):50. doi: 10.1159/000360661. Epub 2014 May 19.
Several organs such as the skin and liver have a great capacity for regeneration. However, many approaches only delay the progression of end-stage kidney disease and do not achieve efficient long-term stabilization, let alone regeneration.
In mammals, the kidney has an innate but limited capacity for regeneration which can only modify the nephron structure and function but not increase the nephron number. Several clinical and animal studies have indicated that functional improvements and/or structural regression can occur in chronic kidney disease. Cell reconstitution, matrix remodeling, and tissue reorganization are major mechanisms for kidney regeneration. Current approaches achieve only partial kidney regeneration, but this does not occur in all animals and is not sustained in the long term. Multipronged and early interventions are future choices for the induction of kidney regeneration.
Kidney regeneration in mammals is feasible but limited and may be enhanced by multitargeting key mechanisms.
皮肤和肝脏等多个器官具有强大的再生能力。然而，许多方法仅能延缓终末期肾病的进展，无法实现有效的长期稳定，更无法实现再生。
在哺乳动物中，肾脏具有与生俱来但有限的再生能力，只能改变肾单位的结构和功能，而不能增加肾单位数量。多项临床和动物研究表明，慢性肾病中可出现功能改善和/或结构逆转。细胞重构、基质重塑和组织重组是肾脏再生的主要机制。目前的方法仅能实现部分肾脏再生，但并非在所有动物中都能出现，且无法长期维持。多方面和早期干预是诱导肾脏再生的未来选择。
哺乳动物的肾脏再生是可行的，但有限，多靶点作用于关键机制可能会增强这种再生能力。
