Gutteridge J M
Molecular Toxicology Research Group, Oklahoma Medical Research Foundation, Oklahoma City 73104.
Acta Paediatr Scand Suppl. 1989;361:78-85. doi: 10.1111/apa.1989.78.s361.78.
Iron is a remarkably useful metal in Nature, but iron ions not safely sequestered in storage or transport proteins are hazardous because they can stimulate damaging free radical reactions. Biological examples of these are Fenton Chemistry leading to the formation of highly reactive species, such as the hydroxyl radical (.OH) and the ferryl ion (FeO2+), and lipid peroxidation. The need to conserve body iron stores has closely evolved with an essential requirement for antioxidant protection and, several 'acute-phase' proteins involved in iron metabolism such as caeruloplasmin, haptoglobins and haemopexin in collaboration with the iron binding proteins transferrin and lactoferrin contribute to our defense against oxidative damage.
铁是自然界中一种非常有用的金属，但未安全螯合在储存或运输蛋白中的铁离子具有危险性，因为它们会引发有害的自由基反应。其中生物学实例包括导致高反应活性物种（如羟基自由基（·OH）和高铁离子（FeO2+））形成的芬顿化学以及脂质过氧化。保存体内铁储备的需求与对抗氧化保护的基本需求密切相关，并且几种参与铁代谢的“急性期”蛋白，如铜蓝蛋白、触珠蛋白和血红素结合蛋白，与铁结合蛋白转铁蛋白和乳铁蛋白协同作用，有助于我们抵御氧化损伤。
