Ramaekers V T, Bosman B, Jansen G A, Wanders R J
Department of Paediatrics, University Hospital Aachen, Germany.
Arch Dis Child. 1997 Sep;77(3):231-4. doi: 10.1136/adc.77.3.231.
Malondialdehyde (MDA) in plasma is regarded as an indicator for increased lipid peroxidation.
Measurements of MDA concentrations in plasma were compared among healthy children (n = 31), patients with neurological disorders or epileptic syndromes (n = 15), and children with pontocerebellar structural defects (n = 31), where the cause or genetic defect remained unknown.
In healthy children the median MDA value was 5.86 nmol/ml (mean (SD) value: 6.25 (1.97), range: 3.76-11.19). For the group with various neurological disorders or epilepsy, the values were similar with the median value at 5.66 nmol/ml (range 0.22-10.86). Compared with healthy controls and the neurological/ epileptic group, the 31 children with pontocerebellar structural defects had significantly increased MDA values with a median value at 11.29 nmol/ml (mean (SD) value: 11.62 (3.27), range 3.65-19.22).
These findings of increased plasma MDA in the majority of children with pontocerebellar structural defects of unknown origin raised the question whether increased lipid peroxidation leads to prenatal and postnatal pontocerebellar maldevelopment or degeneration.
血浆中的丙二醛（MDA）被视为脂质过氧化增加的指标。
比较了健康儿童（n = 31）、患有神经系统疾病或癫痫综合征的患者（n = 15）以及脑桥小脑结构缺陷儿童（n = 31）的血浆MDA浓度，这些脑桥小脑结构缺陷儿童的病因或基因缺陷尚不清楚。
健康儿童的MDA中位数为5.86 nmol/ml（均值（标准差）：6.25（1.97），范围：3.76 - 11.19）。患有各种神经系统疾病或癫痫的组，数值与之相似，中位数为5.66 nmol/ml（范围0.22 - 10.86）。与健康对照组和神经/癫痫组相比，31例脑桥小脑结构缺陷儿童的MDA值显著升高，中位数为11.29 nmol/ml（均值（标准差）：11.62（3.27），范围3.65 - 19.22）。
大多数病因不明的脑桥小脑结构缺陷儿童血浆MDA升高的这些发现，引发了脂质过氧化增加是否导致产前和产后脑桥小脑发育不良或退化的问题。
