Santos Iná S, Matijasevich Alicia, Barros Aluísio J D, Barros Fernando C
Programa de Pós-graduação em Epidemiologia, Universidade Federal de Pelotas, Rua Marechal Deodoro 1160, 3o piso, 96020-220 Pelotas, Brazil.
Programa de Pós-graduação em Epidemiologia, Universidade Federal de Pelotas, Rua Marechal Deodoro 1160, 3o piso, 96020-220 Pelotas, Brazil.
J Affect Disord. 2014 Aug;164(100):112-7. doi: 10.1016/j.jad.2014.04.033. Epub 2014 Apr 19.
Maternal mood symptoms have been associated with psychiatric disorders in children. This study aimed to assess critical periods when maternal symptoms would be more deleterious.
Cohort of 4231 births followed-up in the city of Pelotas, Brazil. Mood symptoms during pregnancy were self-reported by mothers at perinatal interview; and at 3-months postpartum, mothers answered the Self-Reporting Questionnaire. Psychiatric disorders in 6-year-old children were evaluated through the Development and Well-Being Assessment instrument. Odds ratios with 95% confidence intervals (95% CI) were calculated by logistic regression.
Prevalence of mood symptoms in pregnancy was 24.6% (23.2-26.0%) and at three months postpartum 22.5% (21.1-23.9%). Prevalence of mental disorders in children was 13.3% (12.2-14.4%). After adjustment for confounders children of mothers with mood symptoms during pregnancy were 82% more likely of presenting psychiatric disorders than children of mothers that did not (1.82; 1.48-2.25); and the chance of having mental disorders among children whose mothers had positive SRQ-20 at three months postpartum was 87% greater than the observed among children whose mothers had it negative (1.87; 1.50-2.33).
Because maternal anxiety/depression may interfere with interpretation of the child behavior, child׳s mental health being obtained by interviewing the mother is a limitation of this study. Lack of information on other risk factors may have lead to residual confounding on the effect of maternal mood symptoms at three months postpartum.
Children of mothers presenting mood symptoms during pregnancy and in the first months postpartum are more likely to present psychiatric disorders at 6 years of age.
母亲的情绪症状与儿童的精神疾病有关。本研究旨在评估母亲症状何时危害更大的关键时期。
对巴西佩洛塔斯市4231例出生队列进行随访。母亲在围产期访谈时自我报告孕期的情绪症状；产后3个月，母亲回答自填问卷。通过发育与幸福感评估工具评估6岁儿童的精神疾病。通过逻辑回归计算95%置信区间（95%CI）的比值比。
孕期情绪症状的患病率为24.6%（23.2 - 26.0%），产后3个月为22.5%（21.1 - 23.9%）。儿童精神障碍的患病率为13.3%（12.2 - 14.4%）。在对混杂因素进行调整后，孕期有情绪症状的母亲的孩子出现精神疾病的可能性比没有情绪症状的母亲的孩子高82%（1.82；1.48 - 2.25）；产后3个月母亲SRQ - 20呈阳性的儿童患精神疾病的几率比母亲SRQ - 20呈阴性的儿童高87%（1.87；1.50 - 2.33）。
由于母亲的焦虑/抑郁可能会干扰对儿童行为的解读，通过访谈母亲来获取儿童心理健康状况是本研究的一个局限性。缺乏其他风险因素的信息可能导致对产后3个月母亲情绪症状影响的残余混杂。
孕期及产后头几个月有情绪症状的母亲的孩子在6岁时更有可能出现精神疾病。
