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1
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2
Time-dependent release of growth factors from implant surfaces treated with plasma rich in growth factors.富含生长因子的等离子体处理的种植体表面的生长因子时变释放。
J Biomed Mater Res A. 2013 May;101(5):1478-88. doi: 10.1002/jbm.a.34428. Epub 2012 Nov 7.
3
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J Biomed Mater Res B Appl Biomater. 2013 Jan;101(1):28-35. doi: 10.1002/jbm.b.32806. Epub 2012 Sep 15.
4
The effect of controlled release of PDGF-BB from heparin-conjugated electrospun PCL/gelatin scaffolds on cellular bioactivity and infiltration.肝素接枝电纺 PCL/明胶支架中 PDGF-BB 的控制释放对细胞生物活性和浸润的影响。
Biomaterials. 2012 Oct;33(28):6709-20. doi: 10.1016/j.biomaterials.2012.06.017. Epub 2012 Jul 6.
5
Bioactivity of freeze-dried platelet-rich plasma in an adsorbed form on a biodegradable polymer material.冻干粉化富血小板血浆在可生物降解聚合物材料上的吸附形式的生物活性。
Platelets. 2012;23(8):594-603. doi: 10.3109/09537104.2011.645923. Epub 2012 Jan 24.
6
Delivery of VEGF using collagen-coated polycaprolactone scaffolds stimulates angiogenesis.使用胶原涂层聚己内酯支架输送 VEGF 可刺激血管生成。
J Biomed Mater Res A. 2012 Mar;100(3):720-7. doi: 10.1002/jbm.a.34010. Epub 2011 Dec 30.
7
Mechanical testing of electrospun PCL fibers.静电纺丝 PC 纤维的力学性能测试。
Acta Biomater. 2012 Jan;8(1):218-24. doi: 10.1016/j.actbio.2011.08.015. Epub 2011 Aug 22.
8
Incorporating platelet-rich plasma into electrospun scaffolds for tissue engineering applications.将富血小板血浆纳入静电纺丝支架用于组织工程应用。
Tissue Eng Part A. 2011 Nov;17(21-22):2723-37. doi: 10.1089/ten.TEA.2010.0663. Epub 2011 Sep 9.
9
Bioactive electrospun scaffolds delivering growth factors and genes for tissue engineering applications.用于组织工程应用的生物活性电纺支架，递送生长因子和基因。
Pharm Res. 2011 Jun;28(6):1259-72. doi: 10.1007/s11095-010-0320-6. Epub 2010 Nov 19.
10
Growth factor regulation of proliferation and survival of multipotential stromal cells.生长因子对多潜能基质细胞增殖和存活的调节作用。
Stem Cell Res Ther. 2010 Oct 26;1(4):32. doi: 10.1186/scrt32.

涂覆富血小板血浆的可生物降解电纺纳米纤维用于细胞黏附和增殖。

Biodegradable electrospun nanofibers coated with platelet-rich plasma for cell adhesion and proliferation.

作者信息

Diaz-Gomez Luis, Alvarez-Lorenzo Carmen, Concheiro Angel, Silva Maite, Dominguez Fernando, Sheikh Faheem A, Cantu Travis, Desai Raj, Garcia Vanessa L, Macossay Javier

机构信息

Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15872 Santiago de Compostela, Spain; Instituto de Ortopedia y Banco de Tejidos Musculoesqueléticos, Universidad de Santiago de Compostela, 15872 Santiago de Compostela, Spain.

Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15872 Santiago de Compostela, Spain.

出版信息

Mater Sci Eng C Mater Biol Appl. 2014 Jul 1;40:180-8. doi: 10.1016/j.msec.2014.03.065. Epub 2014 Mar 31.

DOI:10.1016/j.msec.2014.03.065
PMID:24857481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4051303/
Abstract

Biodegradable electrospun poly(ε-caprolactone) (PCL) scaffolds were coated with platelet-rich plasma (PRP) to improve cell adhesion and proliferation. PRP was obtained from human buffy coat, and tested on human adipose-derived mesenchymal stem cells (MSCs) to confirm cell proliferation and cytocompatibility. Then, PRP was adsorbed on the PCL scaffolds via lyophilization, which resulted in a uniform sponge-like coating of 2.85 (S.D. 0.14) mg/mg. The scaffolds were evaluated regarding mechanical properties (Young's modulus, tensile stress and tensile strain), sustained release of total protein and growth factors (PDGF-BB, TGF-β1 and VEGF), and hemocompatibility. MSC seeded on the PRP-PCL nanofibers showed an increased adhesion and proliferation compared to pristine PCL fibers. Moreover, the adsorbed PRP enabled angiogenesis features observed as neovascularization in a chicken chorioallantoic membrane (CAM) model. Overall, these results suggest that PRP-PCL scaffolds hold promise for tissue regeneration applications.

摘要

可生物降解的静电纺聚己内酯（PCL）支架用富血小板血浆（PRP）进行了涂层处理，以改善细胞黏附和增殖。PRP取自人血沉棕黄层，并在人脂肪来源的间充质干细胞（MSC）上进行测试，以确认细胞增殖和细胞相容性。然后，通过冻干法将PRP吸附在PCL支架上，形成了均匀的海绵状涂层，涂层量为2.85（标准差0.14）mg/mg。对支架的力学性能（杨氏模量、拉伸应力和拉伸应变）、总蛋白和生长因子（血小板衍生生长因子BB、转化生长因子β1和血管内皮生长因子）的缓释情况以及血液相容性进行了评估。与原始PCL纤维相比，接种在PRP-PCL纳米纤维上的MSC表现出更强的黏附和增殖能力。此外，吸附的PRP在鸡胚绒毛尿囊膜（CAM）模型中呈现出血管生成特征，表现为新血管形成。总体而言，这些结果表明PRP-PCL支架在组织再生应用方面具有潜力。