Vázquez C, Rodríguez-Soriano J
Department of Pediatrics, Hospital Infantil de Cruces, Bilbao, Spain.
Pediatr Pulmonol. 1989;6(2):99-102. doi: 10.1002/ppul.1950060208.
A study was undertaken to assess the variability of results of histamine inhalation tests with the tidal breathing method, keeping the total dose of histamine delivered to the mouth constant but using either different nebulizers or the same Wright nebulizer operated under changing conditions. Seventeen asthmatic children had double histamine bronchial provocation tests with a Bennett-Twin nebulizer (output 0.31 ml/min, nebulization time 1 min) and a Wright nebulizer (output 0.15 ml/min, nebulization time 2 min), with a driving flow rate, in both instances, of 7 L/min. Another group of 15 asthmatic children had double provocation tests with a Wright nebulizer driven by a flow rate of either 7 L/min (output 0.15 ml/min, nebulization time 2 min) or 12 L/min (output 0.30 ml/min, nebulization time 1 min). In each experiment the volume of histamine solution delivered was about 0.30 ml. PC20-FEV1 was significantly lower, indicating an increased bronchial response, when both methods using "faster" delivery of histamine were used. We conclude that comparison of results obtained with histamine inhalation tests by the tidal breathing method cannot be made unless the nebulizer and operating criteria are the same.
进行了一项研究，以评估潮气呼吸法组胺吸入试验结果的变异性，保持输送到口腔的组胺总剂量恒定，但使用不同的雾化器，或在不同条件下操作相同的赖特雾化器。17名哮喘儿童使用贝内特双筒雾化器（输出量0.31毫升/分钟，雾化时间1分钟）和赖特雾化器（输出量0.15毫升/分钟，雾化时间2分钟）进行了两次组胺支气管激发试验，在两种情况下驱动流速均为7升/分钟。另一组15名哮喘儿童使用流速为7升/分钟（输出量0.15毫升/分钟，雾化时间2分钟）或12升/分钟（输出量0.30毫升/分钟，雾化时间1分钟）驱动的赖特雾化器进行了两次激发试验。在每个实验中，输送的组胺溶液体积约为0.30毫升。当使用两种“更快”输送组胺的方法时，PC20-FEV1显著降低，表明支气管反应增强。我们得出结论，除非雾化器和操作标准相同，否则无法对潮气呼吸法组胺吸入试验获得的结果进行比较。
