Zhang Yahui, Yu Yin, Dolati Farzaneh, Ozbolat Ibrahim T
Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242, USA; Biomanufacturing Laboratory, Center for Computer-Aided Design, The University of Iowa, 139 Engineering Research Facility, Iowa City, IA 52242, USA.
Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA; Biomanufacturing Laboratory, Center for Computer-Aided Design, The University of Iowa, 139 Engineering Research Facility, Iowa City, IA 52242, USA.
Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:126-33. doi: 10.1016/j.msec.2014.02.036. Epub 2014 Feb 24.
Due to its abundant source, good biocompatibility, low price and mild crosslinking process, alginate is an ideal selection for tissue engineering applications. In this work, alginate vascular conduits were fabricated through a coaxial extrusion-based system. However, due to the inherent weak mechanical properties of alginate, the vascular conduits are not capable of biomimicking natural vascular system. In this paper, multiwall carbon nanotubes (MWCNT) were used to reinforce vascular conduits. Mechanical, dehydration, swelling and degradation tests were performed to understand influences of MWCNT reinforcement. The unique mechanical properties together with perfusion and diffusional capability are two important factors to mimic the nature. Thus, perfusion experiments were also conducted to explore the MWCNT reinforcement effect. In addition, cell viability and tissue histology were conducted to evaluate the biological performance of conduits both in short and long term for MWCNT reinforcement.
由于藻酸盐来源丰富、生物相容性良好、价格低廉且交联过程温和，它是组织工程应用的理想选择。在这项工作中，通过基于同轴挤压的系统制备了藻酸盐血管导管。然而，由于藻酸盐固有的机械性能较弱，这些血管导管无法模拟天然血管系统。在本文中，多壁碳纳米管（MWCNT）被用于增强血管导管。进行了力学、脱水、肿胀和降解测试，以了解MWCNT增强的影响。独特的机械性能以及灌注和扩散能力是模拟自然的两个重要因素。因此，还进行了灌注实验以探索MWCNT的增强效果。此外，进行了细胞活力和组织组织学检查，以评估MWCNT增强的导管在短期和长期的生物学性能。
