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苯并硼唑的独特化学性质:在生物技术和治疗中的当前及新兴应用

The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments.

作者信息

Liu C Tony, Tomsho John W, Benkovic Stephen J

机构信息

Department of Chemistry, Pennsylvania State University, University Park, PA 16802, United States.

Department of Chemistry & Biochemistry, University of the Sciences, 600 S. 43rd Street, Philadelphia, PA 19104-4495, United States.

出版信息

Bioorg Med Chem. 2014 Aug 15;22(16):4462-73. doi: 10.1016/j.bmc.2014.04.065. Epub 2014 May 10.

Abstract

Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, especially in comparison to their acyclic boronic acid counterparts. Furthermore, the low bio-toxicity combined with the high target specificity associated with benzoxaboroles make them very attractive as therapeutic agents. Herein, we provide an updated summary on the current knowledge of the fundamental chemical reactivity of benzoxaboroles, followed by highlighting their major applications reported to date.

摘要

近年来,苯并硼唑因其在生物传感技术、材料科学和治疗干预等领域的广泛应用而备受关注。部分原因在于苯并硼唑独特的化学性质,尤其是与非环状硼酸类似物相比。此外,苯并硼唑低生物毒性与高靶向特异性相结合,使其作为治疗剂极具吸引力。在此,我们提供了关于苯并硼唑基本化学反应性的当前知识的最新总结,随后重点介绍了迄今为止报道的其主要应用。

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