State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology , Wuhan 430070, People's Republic of China.
ACS Appl Mater Interfaces. 2014 Jun 25;6(12):9897-903. doi: 10.1021/am502729y. Epub 2014 Jun 6.
In this work, we have demonstrated the autonomous motion of biologically-friendly Mg/Pt-Poly(N-isopropylacrylamide) (PNIPAM) Janus micromotors in simulated body fluids (SBF) or blood plasma without any other additives. The pit corrosion of chloride anions and the buffering effect of SBF or blood plasma in removing the Mg(OH)2 passivation layer play major roles for accelerating Mg-H2O reaction to produce hydrogen propulsion for the micromotors. Furthermore, the Mg/Pt-PNIPAM Janus micromotors can effectively uptake, transport, and temperature-control-release drug molecules by taking advantage of the partial surface-attached thermoresponsive PNIPAM hydrogel layers. The PNIPAM hydrogel layers on the micromotors can be easily replaced with other responsive polymers or antibodies by the surface modification strategy, suggesting that the as-proposed micromotors also hold a promising potential for separation and detection of heavy metal ions, toxicants, or proteins.
在这项工作中，我们展示了在模拟体液（SBF）或血浆中，无需任何其他添加剂，生物友好型 Mg/Pt-聚（N-异丙基丙烯酰胺）（PNIPAM）Janus 微马达的自主运动。氯离子的坑蚀和 SBF 或血浆的缓冲作用在去除 Mg(OH)2 钝化层方面起着重要作用，可加速 Mg-H2O 反应，为微马达产生氢推进力。此外，Mg/Pt-PNIPAM Janus 微马达可以通过利用部分表面附着的热敏性 PNIPAM 水凝胶层，有效地摄取、传输和温控释放药物分子。通过表面修饰策略，微马达上的 PNIPAM 水凝胶层可以很容易地被其他响应性聚合物或抗体取代，这表明所提出的微马达在重金属离子、毒物或蛋白质的分离和检测方面也具有很大的潜力。
